公开(公告)号：US20040197832A1

公开(公告)日：2004-10-07

申请号：US10405698

申请日：2003-04-03

Applicant: Mor Research Applications Ltd.

Inventor： Aliza Amiel ,  Moshe D. Fejgin

IPC: G01N033/53 ,  G01N033/567

CPC classification number: C12Q1/6879 ,  C12Q1/6841 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/689 ,  G01N2800/36 ,  G01N2800/368 ,  G01N2800/387

Abstract: A method is provided for determining the gender and/or chromosomal abnormality, e.g. chromosomal aneuploidy of a fetus comprising identifying fetal cells in a transcervical cell sample obtained from a pregnant woman, for example with an antibody specific to the HLA-G antigen expressed only by extravillous trophoblast cells, and then subjecting the identified fetal cells to fluorescence in situ hybridization (FISH) with one or more probes for detecting the sex of the fetus or a chromosomal abnormality such as a monosomy, a trisomy or a polyploidy, e.g. triploidy.

Abstract translation: 提供了一种用于确定性别和/或染色体异常的方法，例如， 胎儿的染色体非整倍性包括鉴定从孕妇获得的子宫颈细胞样品中的胎儿细胞，例如用仅由绒毛滋养层细胞表达的HLA-G抗原特异的抗体，然后使鉴定的胎儿细胞在原位荧光 杂交（FISH）与一个或多个用于检测胎儿性别的探针或染色体异常如单体，三体或多倍体，例如 三倍体