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1.发明授权Heterocyclic derivatives, pharmaceutical compositions and methods of use thereof 有权杂环衍生物，药物组合物及其使用方法公开(公告)号：US08541428B2
公开(公告)日：2013-09-24
申请号：US12438291
申请日：2006-08-22
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72
CPC分类号： C07D239/91 , C07D239/90
摘要： The present invention relates to novel quinoxaline, quinazoline and phthalazine derivatives as well as multimeric derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds for the treatment and prevention of brain damage resulting from brain injury, especially secondary brain damage due to traumatic brain injury (TBI). The compounds of the invention are also useful in treating and preventing neurodegenerative diseases.
摘要翻译： 本发明涉及新颖的喹喔啉，喹唑啉和酞嗪衍生物以及多聚衍生物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物治疗和预防由脑损伤引起的脑损伤的方法，特别是二次 由脑外伤引起的脑损伤（TBI）。 本发明的化合物也可用于治疗和预防神经变性疾病。
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2.发明申请HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF 有权杂环衍生物，药物组合物及其使用方法公开(公告)号：US20100029658A1
公开(公告)日：2010-02-04
申请号：US12438291
申请日：2006-08-22
IPC分类号： A61K31/498 , C07D237/30 , A61K31/502 , C07D239/72 , A61K31/517 , C07D241/36 , C07D217/02 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07D239/91 , C07D239/90
摘要： The present invention relates to novel quinoxaline, quinazoline and phthalazine derivatives as well as multimeric derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds for the treatment and prevention of brain damage resulting from brain injury, especially secondary brain damage due to traumatic brain injury (TBI). The compounds of the invention are also useful in treating and preventing neurodegenerative diseases.
摘要翻译： 本发明涉及新颖的喹喔啉，喹唑啉和酞嗪衍生物以及多聚衍生物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物治疗和预防由脑损伤引起的脑损伤的方法，特别是二次 由脑外伤引起的脑损伤（TBI）。 本发明的化合物也可用于治疗和预防神经变性疾病。
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