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    Synthesis of 1-acetoxy-2-methylnaphthalene
    1.
    发明授权
    Synthesis of 1-acetoxy-2-methylnaphthalene 失效
    1-乙酰氧基-2-甲基萘的合成

    公开(公告)号：US5670698A

    公开(公告)日：1997-09-23

    申请号：US699259

    申请日：1996-08-19

    申请人： Mu-Ill Lim ,  Yuh-Guo Pan ,  Linas Stasaitis ,  James Anderson

    发明人： Mu-Ill Lim ,  Yuh-Guo Pan ,  Linas Stasaitis ,  James Anderson

    IPC分类号： C07C67/297 ,  C07C69/157 ,  C07C69/00

    CPC分类号： C07C67/297 ,  C07C67/18

    摘要： A one pot process is provided in which a Mannich base of the formula 5 is reacted with acetic anhydride to produce a diacetate derivative. Without any intermediate isolation, the derivative is hydrogenated to produce a reaction mixture containing 1-acetoxy-2-methylnaphthalene which is readily precipitated from the reaction mixture by addition of water. ##STR1##

    摘要翻译： 提供一锅法，其中式5的曼尼希碱与乙酸酐反应以产生二乙酸酯衍生物。 在不进行任何中间分离的情况下，将衍生物氢化以产生含有1-乙酰氧基-2-甲基萘的反应混合物，其通过加入水容易地从反应混合物中沉淀。 5

    Method of producing DAI from DOPA, using one reaction vessel
    2.
    发明授权
    Method of producing DAI from DOPA, using one reaction vessel 失效
    使用一个反应容器从DOPA生产DAI的方法

    公开(公告)号：US5486619A

    公开(公告)日：1996-01-23

    申请号：US235763

    申请日：1994-04-29

    申请人： Gottfried Wenke ,  Yuh-Guo Pan ,  Mu-Ill Lim ,  Linas Stasaitis

    发明人： Gottfried Wenke ,  Yuh-Guo Pan ,  Mu-Ill Lim ,  Linas Stasaitis

    IPC分类号： C07D209/08

    CPC分类号： C07D209/08

    摘要： A method of producing and isolating 5,6-diacetoxyindole (DAI) in a single reaction vessel comprising the following steps:(a) preparing a first solution comprising dopa, water and a solubilizing agent selected from the group consisting of an acid having a pk.sub.a value equal to or less than 4 and a first base having a pk.sub.b value equal to or greater than 10;(b) preparing a second solution comprising an oxidant, a buffer and water;(c) mixing the first and second solutions to form a combined solution which is rendered oxygen-free and has a pH of from about 6 to about 9;(d) stirring the combined solution in an inert atmosphere until 5,6-dihydroxyindole (DHI) is substantially completely formed;(e) adding a derivatizing agent and a second base to the combined solution to form a final solution;(f) stirring the final solution until the DHI is substantially fully consumed;(g) cooling the final solution to precipitate DAI;(h) isolating the precipitated DAI.

    摘要翻译： 一种在单个反应容器中生产和分离5,6-二乙酰氧基吲哚（DAI）的方法，包括以下步骤：（a）制备包含多巴，水和增溶剂的第一溶液，所述第一溶液选自具有pka 值等于或小于4，以及pkb值等于或大于10的第一碱基; （b）制备包含氧化剂，缓冲剂和水的第二溶液; （c）混合第一和第二溶液以形成无氧的并具有约6至约9的pH的组合溶液; （d）在惰性气氛中搅拌合并的溶液直到5,6-二羟基吲哚（DHI）基本上完全形成; （e）向组合溶液中加入衍生剂和第二碱以形成最终溶液; （f）搅拌最终溶液直到DHI基本上完全消耗; （g）冷却最终溶液以沉淀DAI; （h）分离析出的DAI。

    Coupler for use in oxidative hair dyeing
    4.
    发明授权
    Coupler for use in oxidative hair dyeing 有权
    用于氧化染发剂的成色剂

    公开(公告)号：US06806372B1

    公开(公告)日：2004-10-19

    申请号：US10404364

    申请日：2003-04-01

    申请人： Mu-Ill Lim ,  Yuh-Guo Pan ,  Margaret Popp

    发明人： Mu-Ill Lim ,  Yuh-Guo Pan ,  Margaret Popp

    IPC分类号： C07D21170

    CPC分类号： A61K8/4926 ,  A61K8/347 ,  A61K8/415 ,  A61Q5/10 ,  C07D213/38

    摘要： Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R2SO4; R3 is selected from C1 to C2 alkyl or hydroxyethyl; R2 is selected from C1 to C22 alkyl and C1 to C22 mono and dihydroxyalkyl; and R is selected from of C1 to C16 alkyl, C1 to C10 hydroxyalkyl, C1 to C6 alkoxyalkyl and benzyl.

    摘要翻译： 用于头发氧化染色的染发组合物的成色剂是式（1）的化合物：其中X选自卤素和R 2 SO 4; R 3选自C 1至C 2烷基或羟乙基; R 2选自C 1至C 22烷基和C 1至C 22单和二羟基烷基; 且R选自C 1至C 16烷基，C 1至C 10羟基烷基，C 1至C 6烷氧基烷基和苄基。

    Coupler for use in oxidative hair dyeing
    5.
    发明授权
    Coupler for use in oxidative hair dyeing 有权
    用于氧化染发剂的成色剂

    公开(公告)号：US06776802B2

    公开(公告)日：2004-08-17

    申请号：US09990626

    申请日：2001-11-16

    申请人： Mu-Ill Lim ,  Yuh-Guo Pan

    发明人： Mu-Ill Lim ,  Yuh-Guo Pan

    IPC分类号： A61K713

    CPC分类号： C07D295/13 ,  A61K8/416 ,  A61Q5/10 ,  C07C215/76 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): wherein X is selected from halogen; R3 is selected from the group consisting of C1 to C2 alkyl and hydroxyethyl; and R, R1 and R2 are each independently selected from C1 to C22 alkyl or C1 to C22 mono or dialkyl groups, or two of R, R1 and R2 together with the the nitrogen atom to which they are attached form a C3 to C6 cycloaliphatic or a C3 to C14 aromatic group, the cycloaliphatic or aromatic group optionally containing in their rings one or more hetero atoms selected from O, S and N atoms.

    摘要翻译： 用于头发氧化染色的染发组合物的成色剂是式（1）的化合物：其中X选自卤素; R 3选自C1-C2烷基和羟乙基; 并且R 1，R 2和R 2各自独立地选自C 1至C 22烷基或C 1至C 22单或二烷基，或R 2，R 1和R 2中的两个与氮原子一起 它们连接在其上形成C3至C6脂环族或C3至C14芳族基团，脂环族或芳族基团任选在其环中含有一个或多个选自O，S和N原子的杂原子。

    Primary intermediates for oxidative coloration of hair
    6.
    发明授权
    Primary intermediates for oxidative coloration of hair 有权
    头发氧化着色的主要中间体

    公开(公告)号：US06774244B2

    公开(公告)日：2004-08-10

    申请号：US10052317

    申请日：2002-01-18

    申请人： Mu-Ill Lim ,  Yuh-Guo Pan

    发明人： Mu-Ill Lim ,  Yuh-Guo Pan

    IPC分类号： C07D20700

    CPC分类号： A61K8/4913 ,  A61K8/415 ,  A61K8/4986 ,  A61Q5/10 ,  C07C215/76

    摘要： Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R is selected from C1 to C5 alkyl or hydroxyalkyl, a C3 to C6 cyclic ring containing hetero atoms selected from O, S and N atoms, and —CH2—Ar where Ar is an aromatic ring wherein the aromatic ring may be substituted with one or two hydroxy C1 to C3 alkoxy, or amino groups.

    摘要翻译： 用于头发氧化染色的染发组合物的主要中间体是式（1）的化合物：其中R选自C 1至C 5烷基或羟烷基，含有选自O，S和N原子的杂原子的C 3至C 6环， 和-CH 2 -Ar，其中Ar是芳环，其中芳环可以被一个或两个羟基C1-C3烷氧基或氨基取代。

    Primary intermediates for oxidative coloration of hair
    7.
    发明授权
    Primary intermediates for oxidative coloration of hair 有权
    头发氧化着色的主要中间体

    公开(公告)号：US06673934B2

    公开(公告)日：2004-01-06

    申请号：US10052734

    申请日：2002-01-18

    申请人： Mu-Ill Lim ,  Yuh-Guo Pan

    发明人： Mu-Ill Lim ,  Yuh-Guo Pan

    IPC分类号： C07D21338

    CPC分类号： C07D319/08 ,  A61K8/347 ,  A61K8/411 ,  A61K8/415 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4973 ,  A61K8/4986 ,  A61Q5/10 ,  C07D213/65 ,  C07D307/58 ,  C07D319/18 ,  C07D333/32

    摘要： Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R is hydrogen, hydroxy, nitro, amino, halogen, C1 to C5 alkyl or haloalkyl, C1 to C5 alkoxy or cyclic alkoxy, C1 to C5 hydroxyalkyl and C1 to C5 hydroxyalkoxy; Ar is an aromatic group, preferably an aromatic group selected from a furanyl, thienyl, pyridinyl, phenyl, 2,3-dihydro-benzo[1,4]dioxin-5 or -6-yl or benzo[1,3]dioxol-4 or -5-yl group; and y=1 to 3.

    摘要翻译： 用于头发氧化染色的染发组合物的主要中间体是式（1）的化合物：其中R是氢，羟基，硝基，氨基，卤素，C 1至C 5烷基或卤代烷基，C 1至C 5烷氧基或环烷氧基，C 1至 C5羟烷基和C1至C5羟基烷氧基; Ar是芳基，优选芳基，选自呋喃基，噻吩基，吡啶基，苯基，2,3-二氢 - 苯并[1,4]二恶英-5或-6-基或苯并[1,3] 4或5-基; y = 1〜3。