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公开(公告)号：US20130011485A1
公开(公告)日：2013-01-10
申请号：US13177034
申请日：2011-07-06
申请人： Mu-Yi HUA , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
发明人： Mu-Yi HUA , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
IPC分类号： A61K9/50 , A61P35/00 , A61K31/785 , B82Y5/00
CPC分类号： A61K47/48861 , A61K9/5094 , A61K31/337 , A61K47/6923 , B82Y5/00 , Y10S977/773 , Y10S977/788 , Y10S977/906
摘要： The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
摘要翻译： 本发明公开了一种用于抑制/治疗人前列腺癌的磁性纳米医药，其包含含有直径小于10nm的磁性颗粒的核心; 由羧基化聚苯胺制成的壳，并封装核心; 和与壳共价连接并能够抑制/治疗前列腺癌的药物。 本发明的磁性纳米医药不仅具有优异的热稳定性，而且还具有比常规抗前列腺癌药物更高的水溶性。 此外，本发明的磁性纳米医药可以磁性地导入癌症区域，以增加药物的局部浓度，增强治疗效果。
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公开(公告)号：US08889192B2
公开(公告)日：2014-11-18
申请号：US13177034
申请日：2011-07-06
申请人： Mu-Yi Hua , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
发明人： Mu-Yi Hua , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
CPC分类号： A61K47/48861 , A61K9/5094 , A61K31/337 , A61K47/6923 , B82Y5/00 , Y10S977/773 , Y10S977/788 , Y10S977/906
摘要： The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
摘要翻译： 本发明公开了一种用于抑制/治疗人前列腺癌的磁性纳米医药，其包含含有直径小于10nm的磁性颗粒的核心; 由羧基化聚苯胺制成的壳，并封装核心; 和与壳共价连接并能够抑制/治疗前列腺癌的药物。 本发明的磁性纳米医药不仅具有优异的热稳定性，而且还具有比常规抗前列腺癌药物更高的水溶性。 此外，本发明的磁性纳米医药可以磁性地导入癌症区域，以增加药物的局部浓度，增强治疗效果。
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公开(公告)号：US20120328705A1
公开(公告)日：2012-12-27
申请号：US13166450
申请日：2011-06-22
申请人： Mu-Yi Hua , Hong-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Rung-Ywan Tsai , Kun-Lung Chuang
发明人： Mu-Yi Hua , Hong-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Rung-Ywan Tsai , Kun-Lung Chuang
IPC分类号： A61K9/51 , A61P35/00 , A61K31/704 , B82Y5/00
CPC分类号： A61K31/704 , A61K9/0009
摘要： A magnetic nanomedicine for tumor suppression and therapy, comprising: a core, made of magnetic nanoparticles; a shell, encapsulating said core and is made of carboxylated polyaniline (SPAnH); and a tumor suppression medicine Epirubicin (EPI) or Doxorubicin (DOX) covalently bonded onto said shell. Said magnetic nanomedicine is capable of improving its thermal stability, and it can be dissolved uniformly in water, plus its superparamagnetic property, thus it can be guided by an outside magnetic field to concentrate to the site of tumor distribution to increase the local medicine concentration and enhance therapy effect.
摘要翻译： 一种用于肿瘤抑制和治疗的磁性纳米医药，包括：由磁性纳米颗粒制成的核心; 壳，封装所述芯并由羧化聚苯胺（SPAnH）制成; 以及共价键合到所述壳上的肿瘤抑制药物表柔比星（EPI）或多柔比星（DOX）。 所述磁性纳米医药能够提高其热稳定性，可以均匀地溶解在水中，加上其超顺磁性，可以通过外界磁场引导，集中到肿瘤分布部位，增加局部药物浓度， 增强疗效。
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公开(公告)号：US08329222B1
公开(公告)日：2012-12-11
申请号：US13166450
申请日：2011-06-22
申请人： Mu-Yi Hua , Hong-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Rung-Ywan Tsai , Kun-Lung Chuang
发明人： Mu-Yi Hua , Hong-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Rung-Ywan Tsai , Kun-Lung Chuang
CPC分类号： A61K31/704 , A61K9/0009
摘要： A magnetic nanomedicine for tumor suppression and therapy, comprising: a core, made of magnetic nanoparticles; a shell, encapsulating said core and is made of carboxylated polyaniline (SPAnH); and a tumor suppression medicine Epirubicin (EPI) or Doxorubicin (DOX) covalently bonded onto said shell. Said magnetic nanomedicine is capable of improving its thermal stability, and it can be dissolved uniformly in water, plus its superparamagnetic property, thus it can be guided by an outside magnetic field to concentrate to the site of tumor distribution to increase the local medicine concentration and enhance therapy effect.
摘要翻译： 一种用于肿瘤抑制和治疗的磁性纳米医药，包括：由磁性纳米颗粒制成的核心; 壳，封装所述芯并由羧化聚苯胺（SPAnH）制成; 以及共价键合到所述壳上的肿瘤抑制药物表柔比星（EPI）或多柔比星（DOX）。 所述磁性纳米医药能够提高其热稳定性，可以均匀地溶解在水中，加上其超顺磁性，可以通过外界磁场引导，集中到肿瘤分布部位，增加局部药物浓度， 增强疗效。
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