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公开(公告)号：US20130011485A1
公开(公告)日：2013-01-10
申请号：US13177034
申请日：2011-07-06
申请人： Mu-Yi HUA , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
发明人： Mu-Yi HUA , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
IPC分类号： A61K9/50 , A61P35/00 , A61K31/785 , B82Y5/00
CPC分类号： A61K47/48861 , A61K9/5094 , A61K31/337 , A61K47/6923 , B82Y5/00 , Y10S977/773 , Y10S977/788 , Y10S977/906
摘要： The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
摘要翻译： 本发明公开了一种用于抑制/治疗人前列腺癌的磁性纳米医药，其包含含有直径小于10nm的磁性颗粒的核心; 由羧基化聚苯胺制成的壳，并封装核心; 和与壳共价连接并能够抑制/治疗前列腺癌的药物。 本发明的磁性纳米医药不仅具有优异的热稳定性，而且还具有比常规抗前列腺癌药物更高的水溶性。 此外，本发明的磁性纳米医药可以磁性地导入癌症区域，以增加药物的局部浓度，增强治疗效果。
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2.发明申请INHIBITION OF BIOFILM FORMATION BY 1,2,3,4,6-PENTA-O-GALLOYL-D-GLUCOPYRANOSE 有权通过1,2,3,4,6-戊二醇-Galloy-D-GLUCOPYRANOSE抑制生物素的形成公开(公告)号：US20120321566A1
公开(公告)日：2012-12-20
申请号：US13236387
申请日：2011-09-19
申请人： Shih-Tung Liu , Mei-Hui Lin , Fang-Rong Chang , Mu-Yi Hua , Hung-Wei Yang
发明人： Shih-Tung Liu , Mei-Hui Lin , Fang-Rong Chang , Mu-Yi Hua , Hung-Wei Yang
IPC分类号： A61K31/7032 , A61Q11/00 , C07H15/207 , A61P17/02 , A61K8/60 , A61K9/68
CPC分类号： C07H13/08 , A01N43/16 , A61K8/60 , A61K9/0014 , A61K9/0056 , A61K9/0058 , A61K9/006 , A61K31/7032 , A61Q11/00 , A61Q17/005 , Y02A50/401 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Disclosed herein are an anti-biofilm composition and a method to inhibit or prevent cell adhesion and/or biofilm formation by a microorganism, in which use of 1,2,3,4,6-penta-O-galloyl-D-glucopyranose (PGG) is involved therein.
摘要翻译： 本文公开了抗生物膜组合物和抑制或预防微生物的细胞粘附和/或生物膜形成的方法，其中使用1,2,3,4,6-五-O-烯丙基-D-吡喃葡萄糖（ PGG）。
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公开(公告)号：US08329064B2
公开(公告)日：2012-12-11
申请号：US12773405
申请日：2010-05-04
申请人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Ruey-Chi Hsu
发明人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Ruey-Chi Hsu
IPC分类号： H01B1/12
摘要： The present invention provides a water-soluble self-acid-doped polyaniline blends, comprising a 70-90% weight percentage polyaniline derivative and 10-30% weight percentage at least a water-soluble polymer. The blend can be used to produce a conductive polymer film and/or a conductive-polymer composite film. In the present invention, a water-soluble self-acid-doped polyaniline derivative is blended with a water-soluble polymer to enhance the mechanical properties and the coating-to-substrate adhesion of the electric conductive polymer film or the electric conductive-polymer composite film, and increase the conductivity of the blender. In addition, the blend containing a water-soluble self-acid-doped polyaniline of the present invention is biotoxicity-free and has free radical-capture capability. Thus it can be used as a biocompatible and conductive biomedical material.
摘要翻译： 本发明提供一种包含70-90％重量百分数聚苯胺衍生物和10-30％重量百分比的至少水溶性聚合物的水溶性自酸掺杂聚苯胺混合物。 该共混物可用于制备导电聚合物膜和/或导电聚合物复合膜。 在本发明中，将水溶性自酸掺杂聚苯胺衍生物与水溶性聚合物共混，以提高导电聚合物膜或导电聚合物复合材料的机械性能和涂层对基材的粘合性 电影，并增加搅拌机的电导率。 此外，含有本发明的水溶性自酸掺杂聚苯胺的共混物是无生物毒性的，具有自由基捕获能力。 因此，它可以用作生物相容和导电的生物医学材料。
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4.发明授权Inhibition of biofilm formation by 1,2,3,4,6-penta-O-galloyl-D-glucopyranose 有权通过1,2,3,4,6-五-O-烯丙基-D-吡喃葡萄糖抑制生物膜形成公开(公告)号：US09181290B2
公开(公告)日：2015-11-10
申请号：US13236387
申请日：2011-09-19
申请人： Shih-Tung Liu , Mei-Hui Lin , Fang-Rong Chang , Mu-Yi Hua , Hung-Wei Yang
发明人： Shih-Tung Liu , Mei-Hui Lin , Fang-Rong Chang , Mu-Yi Hua , Hung-Wei Yang
IPC分类号： C07H15/207 , C07H13/00 , C07H13/08 , A61K8/60 , A61Q11/00 , A61Q17/00 , A01N43/16 , A61K31/7032 , A61K9/00 , A61K9/68
CPC分类号： C07H13/08 , A01N43/16 , A61K8/60 , A61K9/0014 , A61K9/0056 , A61K9/0058 , A61K9/006 , A61K31/7032 , A61Q11/00 , A61Q17/005 , Y02A50/401 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Disclosed herein are an anti-biofilm composition and a method to inhibit or prevent cell adhesion and/or biofilm formation by a microorganism, in which use of 1,2,3,4,6-penta-O-galloyl-D-glucopyranose (PGG) is involved therein.
摘要翻译： 本文公开了抗生物膜组合物和抑制或预防微生物的细胞粘附和/或生物膜形成的方法，其中使用1,2,3,4,6-五-O-烯丙基-D-吡喃葡萄糖（ PGG）。
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5.发明授权Magnetic nanocomposite for inhibiting/treating cancer and method for fabricating the same 有权用于抑制/治疗癌症的磁性纳米复合物及其制造方法公开(公告)号：US08992990B2
公开(公告)日：2015-03-31
申请号：US12799887
申请日：2010-05-04
申请人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Kuo-Chen Wei , Pin-Yuan Chen , Chiung-Yin Huang
发明人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Kuo-Chen Wei , Pin-Yuan Chen , Chiung-Yin Huang
CPC分类号： A61K47/48861 , A61K47/6923
摘要： The present invention discloses a magnetic nanocomposite for inhibiting/treating cancer and a method for fabricating the same. The magnetic nanocomposite comprises a core formed of a plurality of magnetic nanoparticles made of ferric ferrous oxide (Fe3O4); a shell made of a carboxy-functionalized polyaniline; and an anti-tumor medicine bound to the external surface of the shell. The method of the present invention fast fabricates the magnetic nanocomposite in a simple way. The medicine of the present invention has a longer half life and a better thermal stability. The present invention disperses the water-insoluble medicine in water uniformly to decrease the biological rejection. Moreover, the magnetic nanocomposite of the present invention is guided to the nidus by an external magnetic field to increase the local concentration of the medicine and provide an effective chemotherapy. Therefore, the present invention has competitive advantage over the conventional BCNU.
摘要翻译： 本发明公开了一种用于抑制/治疗癌症的磁性纳米复合物及其制造方法。 磁性纳米复合材料包括由多个由三氧化铁（Fe 3 O 4）制成的多个磁性纳米颗粒形成的芯体; 由羧基官能化聚苯胺制成的壳; 以及与外壳的外表面结合的抗肿瘤药物。 本发明的方法以简单的方式快速制造磁性纳米复合材料。 本发明的药物具有更长的半衰期和更好的热稳定性。 本发明将水不溶性药物均匀分散在水中以降低生物排斥。 此外，本发明的磁性纳米复合材料通过外部磁场被引导到内部，以增加药物的局部浓度并提供有效的化学疗法。 因此，本发明比传统的BCNU具有竞争优势。
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6.发明授权Magnetic nanocomposite with multi-biofunctional groups and method for fabricating the same 有权具有多功能组的磁性纳米复合物及其制造方法公开(公告)号：US08974769B2
公开(公告)日：2015-03-10
申请号：US12799893
申请日：2010-05-04
申请人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Kuo-Chen Wei , Pin-Yuan Chen , Hao-Li Liu
发明人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Kuo-Chen Wei , Pin-Yuan Chen , Hao-Li Liu
CPC分类号： A61K47/48661 , A61K47/6875 , A61K47/6923 , A61K49/1857 , B82Y5/00 , Y10S977/892
摘要： The present invention proposes a magnetic nanocomposite with multi-biofunctional groups, which comprises a core and a shell wrapping the core, wherein the core contains magnetic nanoparticles, and wherein the shell is made of a conductive polymer with multi-biofunctional groups where a medicine, an antibody or a fluorescent label can be attached.
摘要翻译： 本发明提出一种具有多生物功能组的磁性纳米复合材料，其包含芯和包裹芯的外壳，其中所述芯包含磁性纳米颗粒，并且其中壳由具有多生物功能基团的导电聚合物制成，其中药物， 可以连接抗体或荧光标记。
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公开(公告)号：US08889192B2
公开(公告)日：2014-11-18
申请号：US13177034
申请日：2011-07-06
申请人： Mu-Yi Hua , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
发明人： Mu-Yi Hua , Hung-Wei Yang , Cheng-Keng Chuang , See-Tong Pang , Hao-Li Liu , Rung-Ywan Tsai , Kun-Lung Chuang
CPC分类号： A61K47/48861 , A61K9/5094 , A61K31/337 , A61K47/6923 , B82Y5/00 , Y10S977/773 , Y10S977/788 , Y10S977/906
摘要： The present invention discloses a magnetic nanomedicine for inhibiting/treating human prostate cancer, which comprises a core containing a magnetic particle having a diameter of less than 10 nm; a shell made of a carboxylated polyaniline and encapsulating the core; and a medicine covalently linked to the shell and able to inhibit/treat prostate cancer. The magnetic nanomedicine of the present invention not only has superior thermal stability and but also has water solubility higher than that of the conventional anti-prostate cancer medicine. Further, the magnetic nanomedicine of the present invention can be magnetically conducted to the cancer area to increase the local concentration of medicine and enhance the therapeutic effect.
摘要翻译： 本发明公开了一种用于抑制/治疗人前列腺癌的磁性纳米医药，其包含含有直径小于10nm的磁性颗粒的核心; 由羧基化聚苯胺制成的壳，并封装核心; 和与壳共价连接并能够抑制/治疗前列腺癌的药物。 本发明的磁性纳米医药不仅具有优异的热稳定性，而且还具有比常规抗前列腺癌药物更高的水溶性。 此外，本发明的磁性纳米医药可以磁性地导入癌症区域，以增加药物的局部浓度，增强治疗效果。
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公开(公告)号：US20130251814A1
公开(公告)日：2013-09-26
申请号：US13620340
申请日：2012-09-14
申请人： Mu-Yi Hua , Hung-Wei Yang , Tony Wu , Rung-Ywan Tsai , Yunn-Hwa Ma , Jyh-Ping Chen
发明人： Mu-Yi Hua , Hung-Wei Yang , Tony Wu , Rung-Ywan Tsai , Yunn-Hwa Ma , Jyh-Ping Chen
IPC分类号： A61K9/51 , A61K31/4365 , A61K31/727 , A61K31/37 , A61P7/02 , A61K31/616 , A61K31/519 , B82Y5/00
CPC分类号： A61K31/519 , A61K9/0009 , A61K9/5094 , A61K31/37 , A61K31/4365 , A61K31/616 , A61K31/727 , A61K33/26 , A61K47/6923 , B82Y5/00
摘要： The present invention discloses a magnetic nanodrug for treating thrombosis, which comprises a core formed of magnetic nanoparticles, a shell enveloping the core and made of carboxyl-functionalized polyaniline, and a thrombosis-treatment drug covalently bonded to the shell. The magnetic nanodrug of the present invention is non-toxic to vascular endothelial cells, has superior stability, features superparamagnetism, and can be uniformly dissolved in water. Therefore, the magnetic nanodrug for treating thrombosis can be guided by an external magnetic field to concentrate on a specified region and increase the effect of thrombosis treatment.
摘要翻译： 本发明公开了一种用于治疗血栓形成的磁性纳米药物，其包括由磁性纳米粒子形成的核心，包封核心并由羧基官能化聚苯胺制成的核心，以及共价键合到壳体上的血栓形成治疗药物。 本发明的磁性纳米药物对血管内皮细胞无毒性，具有优异的稳定性，超顺磁性，可均匀溶于水。 因此，用于治疗血栓形成的磁性纳米药物可以通过外部磁场引导以集中在特定区域并增加血栓形成治疗的效果。
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公开(公告)号：US20110101282A1
公开(公告)日：2011-05-05
申请号：US12773405
申请日：2010-05-04
申请人： Mu-Yi HUA , Hung-Wei Yang , Rung-Ywan Tsai , Ruey-Chi Hsu
发明人： Mu-Yi HUA , Hung-Wei Yang , Rung-Ywan Tsai , Ruey-Chi Hsu
IPC分类号： H01B1/12
摘要： The present invention provides a water-soluble self-acid-doped polyaniline blends, comprising a 70-90% weight percentage polyaniline derivative and 10-30% weight percentage at least a water-soluble polymer. The blend can be used to produce a conductive polymer film and/or a conductive-polymer composite film. In the present invention, a water-soluble self-acid-doped polyaniline derivative is blended with a water-soluble polymer to enhance the mechanical properties and the coating-to-substrate adhesion of the electric conductive polymer film or the electric conductive-polymer composite film, and increase the conductivity of the blender. In addition, the blend containing a water-soluble self-acid-doped polyaniline of the present invention is biotoxicity-free and has free radical-capture capability. Thus it can be used as a biocompatible and conductive biomedical material.
摘要翻译： 本发明提供一种包含70-90％重量百分数聚苯胺衍生物和10-30％重量百分比的至少水溶性聚合物的水溶性自酸掺杂聚苯胺混合物。 该共混物可用于制备导电聚合物膜和/或导电聚合物复合膜。 在本发明中，将水溶性自酸掺杂聚苯胺衍生物与水溶性聚合物共混，以提高导电聚合物膜或导电聚合物复合材料的机械性能和涂层对基材的粘合性 电影，并增加搅拌机的电导率。 此外，含有本发明的水溶性自酸掺杂聚苯胺的共混物是无生物毒性的，具有自由基捕获能力。 因此，它可以用作生物相容和导电的生物医学材料。
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10.发明申请Magnetic nanocomposite for inhibiting/treating cancer and method for fabricating the same 有权用于抑制/治疗癌症的磁性纳米复合物及其制造方法公开(公告)号：US20110104294A1
公开(公告)日：2011-05-05
申请号：US12799887
申请日：2010-05-04
申请人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Kuo-Chen Wei , Pin-Yuan Chen , Chiung-Yin Huang
发明人： Mu-Yi Hua , Hung-Wei Yang , Rung-Ywan Tsai , Kuo-Chen Wei , Pin-Yuan Chen , Chiung-Yin Huang
IPC分类号： A61K9/14 , A61K31/175 , A61K31/16 , A61K31/4015 , A61P35/00
CPC分类号： A61K47/48861 , A61K47/6923
摘要： The present invention discloses a magnetic nanocomposite for inhibiting/treating cancer and a method for fabricating the same. The magnetic nanocomposite comprises a core formed of a plurality of magnetic nanoparticles made of ferric ferrous oxide (Fe3O4); a shell made of a carboxy-functionalized polyaniline; and an anti-tumor medicine bound to the external surface of the shell. The method of the present invention fast fabricates the magnetic nanocomposite in a simple way. The medicine of the present invention has a longer half life and a better thermal stability. The present invention disperses the water-insoluble medicine in water uniformly to decrease the biological rejection. Moreover, the magnetic nanocomposite of the present invention is guided to the nidus by an external magnetic field to increase the local concentration of the medicine and provide an effective chemotherapy. Therefore, the present invention has competitive advantage over the conventional BCNU.
摘要翻译： 本发明公开了一种用于抑制/治疗癌症的磁性纳米复合物及其制造方法。 磁性纳米复合材料包括由多个由三氧化铁（Fe 3 O 4）制成的多个磁性纳米颗粒形成的芯体; 由羧基官能化聚苯胺制成的壳; 以及与外壳的外表面结合的抗肿瘤药物。 本发明的方法以简单的方式快速制造磁性纳米复合材料。 本发明的药物具有更长的半衰期和更好的热稳定性。 本发明将水不溶性药物均匀分散在水中以降低生物排斥。 此外，本发明的磁性纳米复合材料通过外部磁场被引导到内部，以增加药物的局部浓度并提供有效的化学疗法。 因此，本发明比传统的BCNU具有竞争优势。
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