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20 条记录 (耗时 0.046 秒)

    Tricyclic compounds, their production and use
    1.
    发明授权
    Tricyclic compounds, their production and use 失效
    三环化合物，其生产和使用

    公开(公告)号：US06251905B1

    公开(公告)日：2001-06-26

    申请号：US09234876

    申请日：1999-01-21

    申请人： Muneo Takatani ,  Yumiko Shibouta ,  Kiminori Tomimatsu ,  Tetsuji Kawamoto

    发明人： Muneo Takatani ,  Yumiko Shibouta ,  Kiminori Tomimatsu ,  Tetsuji Kawamoto

    IPC分类号： C07D40106

    CPC分类号： C07D471/16

    摘要： Tricyclic compound of the formula: wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.

    摘要翻译： 下式的三环化合物：其中环A是含氮杂环，具有两个氮原子作为杂原子，其任选被氧代或硫代取代; 环Q可任选被取代; Y是任选取代的烃基，任选取代的羟基或任选取代的mecapto基团，不包括甲基作为Y; R1是具有优异的PDGF抑制活性，抗高血压活性，改善肾脏疾病的活性和降低脂质水平的活性的氢原子，卤素原子，任选取代的烃基或酰基或其盐。

    Tricyclic nitrogen ring compounds, their production and use
    2.
    发明授权
    Tricyclic nitrogen ring compounds, their production and use 失效
    三环氮环化合物，其生产和使用

    公开(公告)号：US5958942A

    公开(公告)日：1999-09-28

    申请号：US783101

    申请日：1997-01-14

    申请人： Muneo Takatani ,  Yumiko Shibouta ,  Kiminori Tomimatsu ,  Tetsuji Kawamoto

    发明人： Muneo Takatani ,  Yumiko Shibouta ,  Kiminori Tomimatsu ,  Tetsuji Kawamoto

    IPC分类号： C07D471/16 ,  C07D471/04 ,  A61K31/44 ,  C07D401/06

    CPC分类号： C07D471/16

    摘要： Tricyclic compound of the formula: ##STR1## wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R.sup.1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.

    摘要翻译： 下式的三环化合物：其中环A是含氮杂环，具有两个氮原子作为杂原子，其任选被氧代或硫代基取代; 环Q可任选被取代; Y是任选取代的烃基，任选取代的羟基或任选取代的mecapto基团，不包括甲基作为Y; R1是具有优异的PDGF抑制活性，抗高血压活性，改善肾脏疾病的活性和降低脂质水平的活性的氢原子，卤素原子，任选取代的烃基或酰基或其盐。

    Pyridine derivatives, their production and use
    10.
    发明授权
    Pyridine derivatives, their production and use 失效
    吡啶衍生物，其生产和使用

    公开(公告)号：US5389658A

    公开(公告)日：1995-02-14

    申请号：US81181

    申请日：1993-06-24

    申请人： Muneo Takatani ,  Taketoshi Saijo ,  Kiminori Tomimatsu

    发明人： Muneo Takatani ,  Taketoshi Saijo ,  Kiminori Tomimatsu

    IPC分类号： C07D213/68 ,  C07D213/70 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  A61K31/425

    CPC分类号： C07D213/70 ,  C07D213/68 ,  C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

    摘要： There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine derivative of the formula (I): ##STR1## wherein R is an optionally substituted pyridine ring, X is a oxygen atom or --S(O).sub.n --, wherein n is 0, 1 or 2, A is a bivalent C.sub.1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen or sulfur atom, R.sub.3 is a hydrogen atom or an optionally substituted hydrocarbon residue, R.sub.4 is an optionally substituted hydrocarbon residue or an optionally substituted monocyclic or bicyclic heterocyclic group, R.sub.3 and R.sub.4 may be joined together with the carbamoyl group or the thiocarbamoyl group to which they are attached to form an optionally substituted heterocyclic group, or R.sub.3 or R.sub.4 may be independently attached to A to form a ring, or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier or diluent.

    摘要翻译： 公开了一种用于提供抗炎，解热，止痛，抗过敏，免疫抑制或免疫调节活性的药物组合物，其包含式（I）的吡啶衍生物：其中R是任选取代的吡啶环，X是 氧原子或-S（O）n - ，其中n为0,1或2，A为支链部分可具有取代基的二价C1-15烃基，Y为氧或硫原子，R3为氢原子 或任选取代的烃残基，R4是任选取代的烃残基或任选取代的单环或双环杂环基，R 3和R 4可以与它们所连接的氨基甲酰基或硫代氨基甲酰基连接在一起形成任选取代的杂环 基团或R 3或R 4可以独立地连接到A上以形成环，或其药学上可接受的盐或溶剂合物，以及药学上可接受的载体或稀释剂。