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公开(公告)号：US08702604B2
公开(公告)日：2014-04-22
申请号：US13017307
申请日：2011-01-31
CPC分类号： G06F19/3406 , A61B5/02116 , A61B5/02125 , A61B5/7217 , A61B5/7239 , G06K9/0053 , G16H40/63
摘要： A medical device system including a physiological sensor is configured to perform a method for detecting signal artifact in a signal waveform acquired by the sensor. A signal waveform is sensed in a patient using the physiological sensor and a fiducial point associated with the sensed waveform is identified. A point value is established using the fiducial point. Signal artifact is detected in response to the established point value and an established threshold, and at least a portion of the signal waveform is rejected in response to detecting signal artifact.
摘要翻译： 包括生理传感器的医疗装置系统被配置为执行用于检测由传感器获取的信号波形中的信号伪影的方法。 使用生理传感器在患者中感测到信号波形，并且识别与感测波形相关联的基准点。 使用基准点建立点值。 响应于建立的点值和建立的阈值检测信号伪像，并且响应于检测到信号伪影而拒绝信号波形的至少一部分。
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2.发明申请METHOD AND SYSTEM FOR INTERPRETING HEMODYNAMIC DATA INCORPORATING PATIENT POSTURE INFORMATION 审中-公开用于解释患有病人信息的血液动力学数据的方法和系统公开(公告)号：US20100217135A1
公开(公告)日：2010-08-26
申请号：US12714850
申请日：2010-03-01
CPC分类号： A61N1/3702 , A61N1/36535 , A61N1/36542
摘要： Systems and methods for improving hemodynamic data interpretation by accounting for the effects of patient posture is disclosed. In certain embodiments, a posture signal is acquired and used to categorize hemodynamic data according to posture to facilitate distinguishing posture-related changes in acquired hemodynamic data from those due to pathophysiologic changes. Posture information may be used to normalize data acquired in various postures to facilitate interpretation of such data. Baseline measurements of hemodynamic data acquired in various postures may also be used to subsequently detect changes in patient posture without the need for an implanted posture sensor.
摘要翻译： 公开了通过考虑患者姿势的影响来改善血液动力学数据解释的系统和方法。 在某些实施例中，获取姿势信号并用于根据姿势对血液动力学数据进行分类，以便于将所获得的血液动力学数据中的姿势相关变化与由于病理生理变化引起的姿势相关的变化区分开。 姿势信息可以用于对在各种姿势中获取的数据进行归一化，以便于解释这些数据。 在各种姿势中获取的血液动力学数据的基线测量也可用于随后检测患者姿势的变化，而不需要植入的姿势传感器。
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公开(公告)号：US20110105927A1
公开(公告)日：2011-05-05
申请号：US12609455
申请日：2009-10-30
IPC分类号： A61B5/0402
CPC分类号： A61N1/3702
摘要： An implantable medical device system including a physiological sensor detects signal artifact in a signal waveform acquired by the sensor. Features of individual waveforms in the sensor signal are extracted. Sample waveforms are classified by expert observation into at least two classes including an artifact class. A distribution range for each of the extracted features from the sample waveforms is determined for each of the classes. Waveform classification criteria are established in response to the determined distribution ranges.
摘要翻译： 包括生理传感器的可植入医疗装置系统检测由传感器获取的信号波形中的信号伪影。 提取传感器信号中各波形的特征。 通过专家观察将样本波形分类为至少两个类，包括神器类。 为每个类别确定来自采样波形的每个提取特征的分布范围。 响应于确定的分布范围建立波形分类标准。
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公开(公告)号：US07470233B2
公开(公告)日：2008-12-30
申请号：US11043819
申请日：2005-01-26
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/4519 , A61B5/7239
摘要： The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, Ė/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from Ė/E(t) provides a measure of the inotropic status of the muscle.
摘要翻译： 本发明提供了一种基于从压力或力信号导出的指标来监测肌肉功能的装置和方法。 肌肉功能指数来源于以压力或力波形的第一次导数与相应的瞬时压力或力的比值计算的瞬时肌肉僵直比。 瞬时刚度比E / E（t）以1 /秒为单位，与强键形成速率有关，并受肌肉纤维钙处理性能和细胞内钙浓度的影响。 因此，从E / E（t）得到的指数提供肌肉肌力状态的量度。
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公开(公告)号：US20090299198A1
公开(公告)日：2009-12-03
申请号：US12129955
申请日：2008-05-30
IPC分类号： A61B5/0215 , A61B5/021
CPC分类号： A61B5/0215 , A61B5/02028
摘要： A method for estimating pulmonary artery diastolic pressure, for a single heart beat, includes establishing a time window for sampling and storing pressure data points from a right ventricular pressure transducer. The time window may be established according to predetermined parameters and/or according to one or more triggering events. An approximate time at which the pulmonary artery valve opens is determined, either via the sampled pressure data points, or via another form of more direct monitoring, during the time window, in order to estimate the pulmonary artery diastolic pressure. A plurality of sets of N pressure data points may be collected, from the sampled data, and, for each collected set, a weighted sum is calculated. Each weighted sum may be employed to evaluate a quality of the sampled data and/or to estimate the pulmonary artery diastolic pressure, if the more direct monitoring of the pulmonary artery valve is not employed.
摘要翻译： 用于估计单次心跳的肺动脉舒张压的方法包括建立用于从右心室压力传感器采样和存储压力数据点的时间窗口。 可以根据预定参数和/或根据一个或多个触发事件建立时间窗口。 通过采样的压力数据点或在时间窗口期间通过另一种形式的更直接的监测来确定肺动脉瓣打开的大致时间，以便估计肺动脉舒张压。 可以从采样数据收集多组N个压力数据点，并且对于每个收集的集合，计算加权和。 如果不采用更直接的肺动脉瓣监测，则每个加权和可用于评估采样数据的质量和/或估计肺动脉舒张压。
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公开(公告)号：US08380295B2
公开(公告)日：2013-02-19
申请号：US12609455
申请日：2009-10-30
IPC分类号： A61B5/04
CPC分类号： A61N1/3702
摘要： An implantable medical device system including a physiological sensor detects signal artifact in a signal waveform acquired by the sensor. Features of individual waveforms in the sensor signal are extracted. Sample waveforms are classified by expert observation into at least two classes including an artifact class. A distribution range for each of the extracted features from the sample waveforms is determined for each of the classes. Waveform classification criteria are established in response to the determined distribution ranges.
摘要翻译： 包括生理传感器的可植入医疗装置系统检测由传感器获取的信号波形中的信号伪影。 提取传感器信号中各波形的特征。 通过专家观察将样本波形分类为至少两个类，包括神器类。 为每个类别确定来自采样波形的每个提取特征的分布范围。 响应于确定的分布范围建立波形分类标准。
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公开(公告)号：US20120197088A1
公开(公告)日：2012-08-02
申请号：US13017307
申请日：2011-01-31
CPC分类号： G06F19/3406 , A61B5/02116 , A61B5/02125 , A61B5/7217 , A61B5/7239 , G06K9/0053 , G16H40/63
摘要： A medical device system including a physiological sensor is configured to perform a method for detecting signal artifact in a signal waveform acquired by the sensor. A signal waveform is sensed in a patient using the physiological sensor and a fiducial point associated with the sensed waveform is identified. A point value is established using the fiducial point. Signal artifact is detected in response to the established point value and an established threshold, and at least a portion of the signal waveform is rejected in response to detecting signal artifact.
摘要翻译： 包括生理传感器的医疗装置系统被配置为执行用于检测由传感器获取的信号波形中的信号伪影的方法。 使用生理传感器在患者中感测到信号波形，并且识别与感测波形相关联的基准点。 使用基准点建立点值。 响应于建立的点值和建立的阈值检测信号伪像，并且响应于检测到信号伪影而拒绝信号波形的至少一部分。
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公开(公告)号：US07935062B2
公开(公告)日：2011-05-03
申请号：US11045574
申请日：2005-01-27
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/029 , A61B5/7239
摘要： The present invention provides a system and method for estimating a blood flow waveform contour from a pressure signal. An arterial or ventricular pressure signal is acquired from a pressure sensor. Landmark points are identified on the pressure waveform that correspond to features of a flow waveform. In one embodiment, the landmark pressure waveform points correspond to the onset of flow, the peak flow, and the end of the systolic ejection phase. The landmark pressure waveform points define a contour that approximates the flow contour. Beat-by-beat flow contour estimation can be performed to allow computation of flow-related hemodynamic parameters such as stroke volume or cardiac output for use in patient monitoring and/or therapy management.
摘要翻译： 本发明提供一种用于从压力信号估计血流波形轮廓的系统和方法。 从压力传感器获取动脉或心室压力信号。 在与流量波形的特征对应的压力波形上标识地标点。 在一个实施例中，标记压力波形点对应于流动的开始，峰值流动和收缩期喷射阶段的结束。 界标压力波形点定义近似流轮廓的轮廓。 可以进行逐搏流轮廓估计，以允许计算流动相关的血液动力学参数，例如用于患者监测和/或治疗管理的中风体积或心输出量。
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9.发明授权公开(公告)号：US08211028B2
公开(公告)日：2012-07-03
申请号：US12112544
申请日：2008-04-30
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/02108 , A61B5/0456 , A61B5/7239 , A61N1/36564
摘要： A system and method of determining hemodynamic parameters uses sensed ventricular blood pressure during a portion of ventricular pressure waveform following peak pressure. An estimated arterial diastolic pressure is based upon an amplitude of the sensed ventricular pressure corresponding to a time at which a first derivative of ventricular pressure as a function of time is at a minimum (dP/dtmin). Fill parameters such as isovolumetric relaxation constant, ventricular suction pressure, atrial kick pressure, and transvalve pressure gradient are derived from measured pressures representing minimum ventricular pressure, ventricular diastolic pressure, and diastasis pressure.
摘要翻译： 确定血液动力学参数的系统和方法在峰值压力之后的心室压力波形的一部分期间使用感测到的心室血压。 估计的动脉舒张压基于对应于作为时间的函数的心室压力的一阶导数在最小（dP / dtmin）的时间的感测的心室压力的幅度。 从表示最小心室压力，心室舒张压和舒张压的测量压力导出填充参数，例如等容舒张常数，心室吸入压力，心房踢压力和转化压力梯度。
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10.发明申请SYSTEM AND METHOD OF DETERMINING ARTERIAL BLOOD PRESSURE AND VENTRICULAR FILL PARAMETERS FROM VENTRICULAR BLOOD PRESSURE WAVEFORM DATA 有权从血管内血压波形数据中确定血管内血压和静脉灌注参数的系统和方法公开(公告)号：US20090275843A1
公开(公告)日：2009-11-05
申请号：US12112544
申请日：2008-04-30
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/02108 , A61B5/0456 , A61B5/7239 , A61N1/36564
摘要： A system and method of determining hemodynamic parameters uses sensed ventricular blood pressure during a portion of ventricular pressure waveform following peak pressure. An estimated arterial diastolic pressure is based upon an amplitude of the sensed ventricular pressure corresponding to a time at which a first derivative of ventricular pressure as a function of time is at a minimum (dP/dtmin). Fill parameters such as isovolumetric relaxation constant, ventricular suction pressure, atrial kick pressure, and transvalve pressure gradient are derived from measured pressures representing minimum ventricular pressure, ventricular diastolic pressure, and diastasis pressure.
摘要翻译： 确定血液动力学参数的系统和方法在峰值压力之后的心室压力波形的一部分期间使用感测到的心室血压。 估计的动脉舒张压基于对应于作为时间的函数的心室压力的一阶导数在最小（dP / dtmin）的时间的感测的心室压力的幅度。 从表示最小心室压力，心室舒张压和舒张压的测量压力导出填充参数，例如等容舒张常数，心室吸入压力，心房踢压力和转化压力梯度。
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