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公开(公告)号：US07470233B2
公开(公告)日：2008-12-30
申请号：US11043819
申请日：2005-01-26
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/4519 , A61B5/7239
摘要： The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, Ė/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from Ė/E(t) provides a measure of the inotropic status of the muscle.
摘要翻译： 本发明提供了一种基于从压力或力信号导出的指标来监测肌肉功能的装置和方法。 肌肉功能指数来源于以压力或力波形的第一次导数与相应的瞬时压力或力的比值计算的瞬时肌肉僵直比。 瞬时刚度比E / E（t）以1 /秒为单位，与强键形成速率有关，并受肌肉纤维钙处理性能和细胞内钙浓度的影响。 因此，从E / E（t）得到的指数提供肌肉肌力状态的量度。
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公开(公告)号：US08706235B2
公开(公告)日：2014-04-22
申请号：US13192116
申请日：2011-07-27
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61B5/042 , A61B5/0452 , A61B5/0538 , A61N1/36185 , A61N1/371 , A61N1/37241
摘要： A system and method for delivering a nerve stimulation therapy determines whether a cardiac EGM signal can be sensed by a bipolar pair of electrodes selected from a number of electrodes positioned for stimulating a nerve. In response to not being able to sense a cardiac signal using the bipolar pair, stimulation of the nerve using a selected pair of the electrodes is enabled.
摘要翻译： 用于递送神经刺激疗法的系统和方法确定心脏EGM信号是否可以被选自用于刺激神经的多个电极的双极电极对感测。 响应于不能使用双极对感测心脏信号，使得能够使用所选择的一对电极刺激神经。
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公开(公告)号：US20130030497A1
公开(公告)日：2013-01-31
申请号：US13192195
申请日：2011-07-27
CPC分类号： A61B5/686 , A61B5/02055 , A61B5/0488 , A61B5/0809 , A61B5/0816 , A61N1/3611 , A61N1/36139
摘要： A system and associated method deliver a respiration therapy. Stimulation pulse trains are delivered to activate a first portion of a patient's diaphragm at an established intended induced respiration rate during a time interval. Stimulation pulse trains are delivered to activate a second portion of a patient's diaphragm at a second rate during the time interval, the second rate being different than the first rate.
摘要翻译： 系统和相关方法提供呼吸治疗。 递送刺激脉冲串以在时间间隔期间以所建立的预期诱导呼吸速率激活患者隔膜的第一部分。 递送刺激脉冲串以在时间间隔期间以第二速率激活患者隔膜的第二部分，第二速率不同于第一速率。
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公开(公告)号：US20130030498A1
公开(公告)日：2013-01-31
申请号：US13192256
申请日：2011-07-27
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/36139 , A61N1/36178
摘要： A system and associated method deliver a respiration therapy. Stimulation pulses are delivered to activate a right portion of a patient's diaphragm and to activate a left portion of a patient's diaphragm. A control processor determines dyssynchrony of a respiratory response to the stimulation pulses and adjusts a stimulation control parameter controlling the delivering of the stimulation pulses in response to dyssynchrony of the respiratory response.
摘要翻译： 系统和相关方法提供呼吸治疗。 输送刺激脉冲以激活患者隔膜的右侧部分并激活患者隔膜的左侧部分。 控制处理器确定对刺激脉冲的呼吸响应的不同步，并且调整响应于呼吸响应的不同步来控制刺激脉冲的传递的刺激控制参数。
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公开(公告)号：US08805511B2
公开(公告)日：2014-08-12
申请号：US13192029
申请日：2011-07-27
IPC分类号： A61N1/08
CPC分类号： A61B5/686 , A61B5/0538 , A61B5/0809 , A61B5/14503 , A61N1/3611 , A61N1/36135
摘要： A medical device and associated method detect ischemia using stimulation delivered to induce respiration. A spontaneous breathing response to the stimulation-induced respiration is determined. Ischemia is detected in response to the spontaneous breathing response. The spontaneous breathing response is measured as a response to adjusting a parameter controlling the stimulation.
摘要翻译： 医疗装置和相关方法使用递送的刺激来检测缺血以诱导呼吸。 确定对刺激诱发的呼吸的自发呼吸反应。 根据自发性呼吸反应检测到缺血。 测量自发呼吸响应作为调整控制刺激的参数的响应。
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公开(公告)号：US20130030496A1
公开(公告)日：2013-01-31
申请号：US13192116
申请日：2011-07-27
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61B5/042 , A61B5/0452 , A61B5/0538 , A61N1/36185 , A61N1/371 , A61N1/37241
摘要： A system and method for delivering a nerve stimulation therapy determines whether a cardiac EGM signal can be sensed by a bipolar pair of electrodes selected from a number of electrodes positioned for stimulating a nerve. In response to not being able to sense a cardiac signal using the bipolar pair, stimulation of the nerve using a selected pair of the electrodes is enabled.
摘要翻译： 用于递送神经刺激疗法的系统和方法确定心脏EGM信号是否可以被选自用于刺激神经的多个电极的双极电极对感测。 响应于不能使用双极对感测心脏信号，使得能够使用所选择的一对电极刺激神经。
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公开(公告)号：US20130030495A1
公开(公告)日：2013-01-31
申请号：US13192029
申请日：2011-07-27
CPC分类号： A61B5/686 , A61B5/0538 , A61B5/0809 , A61B5/14503 , A61N1/3611 , A61N1/36135
摘要： A medical device and associated method detect ischemia using stimulation delivered to induce respiration. A spontaneous breathing response to the stimulation-induced respiration is determined. Ischemia is detected in response to the spontaneous breathing response. The spontaneous breathing response is measured as a response to adjusting a parameter controlling the stimulation.
摘要翻译： 医疗装置和相关方法使用递送的刺激来检测缺血以诱导呼吸。 确定对刺激诱发的呼吸的自发呼吸反应。 根据自发性呼吸反应检测到缺血。 测量自发呼吸响应作为调整控制刺激的参数的响应。
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公开(公告)号：US20120290036A1
公开(公告)日：2012-11-15
申请号：US13103735
申请日：2011-05-09
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61B5/0452 , A61B5/0826 , A61B5/4836 , A61B5/686 , A61N1/3601 , F04C2270/0421
摘要： A method includes estimating a cardiac signal of a patient, estimating a length of a cardiac refractory period based in part on the cardiac signal and selectively adjusting the length of phrenic nerve electrical stimulation to be delivered to the patient based on the estimated length of the cardiac refractory period. In some examples the method includes delivering phrenic nerve stimulation for approximately the entire refractory period. The phrenic nerve stimulation may be used to treat a variety of breathing disorders.
摘要翻译： 一种方法包括估计患者的心脏信号，部分地基于心脏信号估计心脏不应期的长度，并且基于估计的心脏长度来选择性地调节要递送给患者的膈神经电刺激的长度 不应期。 在一些实例中，该方法包括在大约整个不应期内输送膈神经刺激。 膈神经刺激可用于治疗各种呼吸障碍。
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公开(公告)号：US20130289636A1
公开(公告)日：2013-10-31
申请号：US13652815
申请日：2012-10-16
CPC分类号： A61N1/36167 , A61N1/3606 , A61N1/3962
摘要： Pulseless electrical activity (PEA) is reduced or eliminated. A medical electrical lead is implanted to deliver high voltage therapy to a fibrillating heart. Another medical electrical lead delivers electrical stimulation through an electrode proximate phrenic nerve tissue in response to the delivery of high voltage therapy to the fibrillating heart.
摘要翻译： 无脉动电活动（PEA）减少或消除。 植入医用电导线以将高电压治疗提供给原纤维心脏。 响应于向原纤维心脏递送高电压治疗，另一医疗电导线通过靠近膈神经组织的电极进行电刺激。
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公开(公告)号：US08504158B2
公开(公告)日：2013-08-06
申请号：US13103735
申请日：2011-05-09
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61B5/0452 , A61B5/0826 , A61B5/4836 , A61B5/686 , A61N1/3601 , F04C2270/0421
摘要： A method includes estimating a cardiac signal of a patient, estimating a length of a cardiac refractory period based in part on the cardiac signal and selectively adjusting the length of phrenic nerve electrical stimulation to be delivered to the patient based on the estimated length of the cardiac refractory period. In some examples the method includes delivering phrenic nerve stimulation for approximately the entire refractory period. The phrenic nerve stimulation may be used to treat a variety of breathing disorders.
摘要翻译： 一种方法包括估计患者的心脏信号，部分地基于心脏信号估计心脏不应期的长度，并且基于估计的心脏长度来选择性地调节要递送给患者的膈神经电刺激的长度 不应期。 在一些实例中，该方法包括在大约整个不应期内输送膈神经刺激。 膈神经刺激可用于治疗各种呼吸障碍。
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