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公开(公告)号：US20110071150A1
公开(公告)日：2011-03-24
申请号：US12888701
申请日：2010-09-23
申请人： Muzaffar Alam , Daisy Joe Du Bois , Ronald Charles Hawley , Joshua Kennedy-Smith , Ana Elena Minatti , Wylie Solang Palmer , Tania Silva , Robert Stephen Wilhelm
发明人： Muzaffar Alam , Daisy Joe Du Bois , Ronald Charles Hawley , Joshua Kennedy-Smith , Ana Elena Minatti , Wylie Solang Palmer , Tania Silva , Robert Stephen Wilhelm
IPC分类号： A61K31/5355 , C07D403/02 , C07D235/04 , C07D417/14 , C07D277/20 , C07D401/14 , C07D263/30 , C07D403/14 , C07D413/14 , A61K31/4178 , A61K31/4155 , A61K31/443 , A61K31/427 , A61K31/444 , A61K31/422 , A61K31/495 , A61K31/506 , A61P11/06 , A61P11/08
CPC分类号： C07D403/04 , C07D209/18 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).
摘要翻译： 式I化合物或其药学上可接受的盐，其中R 1，R 2，R 3和R 4如本文所定义。 还公开了制备化合物和使用该化合物治疗与钙释放激活的钙通道（CRAC）相关的疾病的方法。
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公开(公告)号：US20120230951A1
公开(公告)日：2012-09-13
申请号：US13414854
申请日：2012-03-08
申请人： Muzaffar Alam , Steven Joseph Berthel , John A. Brinkman , Ronald Charles Hawley , Hongju Li , Wylie Solang Palmer , Sherrie Pietranico-Cole , Ramakanth Sarabu , Mark Smith , Sung-Sau So , Lin Yi , Yansheng Zhai , Qiang Zhang , Shu-Hai Zhao
发明人： Muzaffar Alam , Steven Joseph Berthel , John A. Brinkman , Ronald Charles Hawley , Hongju Li , Wylie Solang Palmer , Sherrie Pietranico-Cole , Ramakanth Sarabu , Mark Smith , Sung-Sau So , Lin Yi , Yansheng Zhai , Qiang Zhang , Shu-Hai Zhao
IPC分类号： A61K31/55 , A61P37/02 , A61P31/14 , A61K38/21 , C07D487/06 , A61K31/551
CPC分类号： C07D487/06 , A61K31/55 , A61K31/551 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译： 本发明提供用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US20080045511A1
公开(公告)日：2008-02-21
申请号：US11893349
申请日：2007-08-15
IPC分类号： A61K31/415 , A61K31/341 , A61K31/416 , A61K31/427 , A61K31/437 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/50 , A61K31/5025 , A61K31/513 , A61K31/519 , A61K31/538 , A61K31/551 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61P31/12 , A61P31/18 , C07D231/12 , C07D231/56 , C07D237/14 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译： 本发明提供了可用于治疗HIV感染或预防HIV感染或治疗AIDS或ARC的化合物。 本发明的化合物具有式I的化合物，其中A为A 1，A 2，A 3或A 4，R 1，R 2，R 3， R 4a，R 4b，R 5，R 6，Ar，X 1，O 2， >，X 2，X 4，X 4和X 5如本文所定义。 本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。
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公开(公告)号：US07713974B2
公开(公告)日：2010-05-11
申请号：US11893349
申请日：2007-08-15
IPC分类号： C07D487/04 , A61K31/4985 , A61P31/18 , C07D231/20 , C07D231/12 , C07D231/56 , A61K31/415 , A61K31/407 , A61K31/519 , C07D471/04
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译： 本发明提供了可用于治疗HIV感染或预防HIV感染或治疗AIDS或ARC的化合物。 本发明的化合物是式Ⅰ化合物，其中A是A 1，A 2，A 3或A 4，R 1，R 2，R 3，R 4a，R 4b，R 5，R 6，Ar，X 1，X 2，X 4，X 4和X 5如本文所定义。 本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。
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公开(公告)号：US08063064B2
公开(公告)日：2011-11-22
申请号：US12708466
申请日：2010-02-18
IPC分类号： C07D471/04 , A61K31/437 , A61P31/18
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A2 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译： 本发明提供了可用于治疗HIV感染或预防HIV感染或治疗AIDS或ARC的化合物。 本发明化合物是式Ⅰ化合物，其中A是A2，R 1，R 2，R 3，R 4a，R 4b，R 5，R 6，Ar，X 1，X 2，X 4，X 4和X 5如本文所定义。 本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。
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公开(公告)号：US20110059975A1
公开(公告)日：2011-03-10
申请号：US12708466
申请日：2010-02-18
IPC分类号： A61K31/5025 , C07D231/12 , A61K31/415 , C07D231/56 , A61K31/416 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61K31/4985 , C07D237/24 , A61K31/50 , A61P31/18
CPC分类号： C07D471/04 , C07D231/12 , C07D231/56 , C07D487/04
摘要： The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A2 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
摘要翻译： 本发明提供了可用于治疗HIV感染或预防HIV感染或治疗AIDS或ARC的化合物。 本发明化合物是式Ⅰ化合物，其中A是A2，R 1，R 2，R 3，R 4a，R 4b，R 5，R 6，Ar，X 1，X 2，X 4，X 4和X 5如本文所定义。 本发明还公开了用本文定义的化合物治疗HIV感染的方法和含有所述化合物的药物组合物。
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公开(公告)号：US20080146565A1
公开(公告)日：2008-06-19
申请号：US12001021
申请日：2007-12-07
申请人： James Patrick Dunn , Leyi Gong , David Michael Goldstein , Xiaochun Han , Joan Heather Hogg , Wylie Solang Palmer , Lubica Raptova , Tania Silva , Parcharee Tivitmahaisoon , Teresa Alejandra Trejo-Martin , Christophe Michoud , Achyutharao Sidduri
发明人： James Patrick Dunn , Leyi Gong , David Michael Goldstein , Xiaochun Han , Joan Heather Hogg , Wylie Solang Palmer , Lubica Raptova , Tania Silva , Parcharee Tivitmahaisoon , Teresa Alejandra Trejo-Martin , Christophe Michoud , Achyutharao Sidduri
IPC分类号： A61K31/506 , A61P29/00 , C07D413/04 , A61K31/5377 , C07D413/14 , C07D471/04 , C07D403/04
CPC分类号： C07D403/04 , C07D471/04 , C07D487/04
摘要： Compounds of formula I modulate JNK: wherein the variables are as defined herein.
摘要翻译： 式I的化合物调节JNK：其中变量如本文所定义。
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公开(公告)号：US08399462B2
公开(公告)日：2013-03-19
申请号：US12001021
申请日：2007-12-07
申请人： James Patrick Dunn , Leyi Gong , David Michael Goldstein , Xiaochun Han , Joan Heather Hogg , Wylie Solang Palmer , Lubica Raptova , Tania Silva , Parcharee Tivitmahaisoon , Teresa Alejandra Trejo-Martin , Christophe Michoud , Achyutharao Sidduri
发明人： James Patrick Dunn , Leyi Gong , David Michael Goldstein , Xiaochun Han , Joan Heather Hogg , Wylie Solang Palmer , Lubica Raptova , Tania Silva , Parcharee Tivitmahaisoon , Teresa Alejandra Trejo-Martin , Christophe Michoud , Achyutharao Sidduri
IPC分类号： C07D403/04 , A61K31/506
CPC分类号： C07D403/04 , C07D471/04 , C07D487/04
摘要： Compounds of formula I modulate JNK: wherein the variables are as defined herein.
摘要翻译： 式I的化合物调节JNK：其中变量如本文所定义。
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公开(公告)号：US08183254B2
公开(公告)日：2012-05-22
申请号：US12454210
申请日：2009-05-14
申请人： Humberto Bartolome Arzeno , James Patrick Dunn , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Alam Jahangir , Wylie Solang Palmer , Deborah Carol Reuter , Tania Silva , Parcharee Tivitmahaisoon , Teresa Alejandra Trejo-Martin , Shao-Yong Wu
发明人： Humberto Bartolome Arzeno , James Patrick Dunn , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Alam Jahangir , Wylie Solang Palmer , Deborah Carol Reuter , Tania Silva , Parcharee Tivitmahaisoon , Teresa Alejandra Trejo-Martin , Shao-Yong Wu
IPC分类号： C07D401/14 , A61K31/506
CPC分类号： C07D401/14
摘要： The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula I: wherein m, n, p, q, Q, r, R1, R2, R3, X, X1, X2, X3, X4, X5, Y1, Y2, Z1 and Z2 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
摘要翻译： 本发明涉及JNK抑制剂的前药以及用于抑制JNK和治疗JNK介导的病症的相应方法，制剂和组合物。 本申请公开了如下式I所述的JNK抑制剂的前药：其中m，n，p，q，Q，r，R1，R2，R3，X，X1，X2，X3，X4，X5，Y1， Z1和Z2如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。 公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及本文公开的化合物，以及制备所述化合物的方法和相应的组合物。
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公开(公告)号：US20090318484A1
公开(公告)日：2009-12-24
申请号：US12454210
申请日：2009-05-14
申请人： Humberto Bartolome Arzeno , James Patrick Dunn , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Alam Jahangir , Wylie Solang Palmer , Deborah Carol Reuter , Tania Silva , Parcharee Tivitmanhaisoon , Teresa Alejandra Trejo-Martin , Shao-Yong Wu
发明人： Humberto Bartolome Arzeno , James Patrick Dunn , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Alam Jahangir , Wylie Solang Palmer , Deborah Carol Reuter , Tania Silva , Parcharee Tivitmanhaisoon , Teresa Alejandra Trejo-Martin , Shao-Yong Wu
IPC分类号： A61K31/506 , C07D413/14 , A61P19/02 , A61P3/04 , A61P25/16 , A61P25/28
CPC分类号： C07D401/14
摘要： The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula I: wherein m, n, p, q, Q, r, R1, R2, R3, X, X1, X2, X3, X4, X5, Y1, Y2, Z1 and Z2 areas defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
摘要翻译： 本发明涉及JNK抑制剂的前药以及用于抑制JNK和治疗JNK介导的病症的相应方法，制剂和组合物。 本申请公开了如下式I所述的JNK抑制剂的前药：其中m，n，p，q，Q，r，R1，R2，R3，X，X1，X2，X3，X4，X5，Y1， Z1和Z2区域。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。 公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及本文公开的化合物，以及制备所述化合物的方法和相应的组合物。
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