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公开(公告)号：US20100261652A1
公开(公告)日：2010-10-14
申请号：US12749507
申请日：2010-03-29
CPC分类号： A61L24/108 , A61F9/007 , A61L2430/16
摘要： There is provided in one embodiment of the disclosure a tissue adhesive composition comprising an engineered protein having repeated blocks of an elastin domain and at least one cell-binding domain and further comprising a polymer crosslinker. When the engineered protein and the polymer crosslinker are introduced onto a tissue, the engineered protein and the polymer crosslinker initiate an in situ crosslinking reaction to form an adhesive bond that is mechanically strong, transparent, biocompatible, and stimulates regrowth of one or more tissue layers over the adhesive bond. In another embodiment of the disclosure there is provided a molded corneal onlay and method of making the same.
摘要翻译： 在本公开的一个实施方案中提供了组织粘合剂组合物，其包含具有弹性蛋白结构域和至少一个细胞结合结构域的重复嵌段的工程改造的蛋白质，并且还包含聚合物交联剂。 当将工程蛋白质和聚合物交联剂引入到组织上时，工程改造的蛋白质和聚合物交联剂引发原位交联反应以形成机械强度，透明度，生物相容性和刺激一个或多个组织层的再生长的粘合剂粘合 超过粘合剂粘合。 在本公开的另一个实施方案中，提供了一种模制的角膜嵌体及其制备方法。
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2.发明申请PHOTOCHEMICAL THERAPY TO AFFECT MECHANICAL AND/OR CHEMICAL PROPERTIES OF BODY TISSUE 有权影响身体组织的机械和/或化学特性的光化学治疗公开(公告)号：US20080114283A1
公开(公告)日：2008-05-15
申请号：US11923575
申请日：2007-10-24
IPC分类号： A61M5/00
CPC分类号： A61K9/0048 , A61F9/0079 , A61F9/008 , A61F2009/00865 , A61F2009/00872 , A61F2009/00893 , A61K9/0051 , A61K9/19 , A61K31/00
摘要： The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.
摘要翻译： 本公开涉及改变身体组织，特别是眼组织的机械和/或化学性质。 在具体情况下，它涉及改变或稳定角膜的形状，例如患有或具有扩张或圆锥角膜风险的受试者。 在其他具体情况下，它涉及加强遭受或面临近视眼的受试者的巩膜。 本发明使用例如对组织进行交联的可光活化化合物的光照射。
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公开(公告)号：US07727544B2
公开(公告)日：2010-06-01
申请号：US11124673
申请日：2005-05-09
申请人： Daniel M. Schwartz , Chang Jun Yu , Robert H. Grubbs , Julia A. Kornfield , Scott E. Fraser , Matthew S. Mattson
发明人： Daniel M. Schwartz , Chang Jun Yu , Robert H. Grubbs , Julia A. Kornfield , Scott E. Fraser , Matthew S. Mattson
CPC分类号： A61K31/135 , A61K31/295 , A61K31/325 , A61K31/37 , A61K31/382 , A61K31/47 , A61K31/495 , A61K41/0042 , A61K49/0002
摘要： The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and/or prevention of myopia. An activating energy source is utilized to photopolymerize or crosslink molecules in the sclera, thereby increasing the strength of the tissue. The individual is administered a crosslinking reagent or photopolymerizable molecule that becomes associated with the membrane, which is then precisely exposed to an energy source, such as light or ultrasound.
摘要翻译： 本发明涉及改变眼睛中至少一个组织的至少一部分的物理和/或化学性质。 在具体实施方案中，其涉及治疗和/或预防近视。 活化能源用于光聚合或交联巩膜中的分子，从而增加组织的强度。 给个体施用交联剂或可光聚合的分子，其与膜相关联，然后将其精确地暴露于能量源，例如光或超声波。
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4.发明授权Photochemical therapy to affect mechanical and/or chemical properties of body tissue 有权光化学疗法影响身体组织的机械和/或化学性质公开(公告)号：US08414911B2
公开(公告)日：2013-04-09
申请号：US11923575
申请日：2007-10-24
申请人： Matthew S. Mattson , Julia A. Kornfield , Daniel M. Schwartz , Robert K. Maloney , Robert H. Grubbs
发明人： Matthew S. Mattson , Julia A. Kornfield , Daniel M. Schwartz , Robert K. Maloney , Robert H. Grubbs
CPC分类号： A61K9/0048 , A61F9/0079 , A61F9/008 , A61F2009/00865 , A61F2009/00872 , A61F2009/00893 , A61K9/0051 , A61K9/19 , A61K31/00
摘要： The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the cornea, such as in a subject suffering or at risk for ectasia or keratoconus. In other specific cases, it concerns strengthening the sclera in a subject suffering or at risk for myopia. The invention employs light irradiation of a photoactivatable compound, such as one that applies crosslinking to the tissue, for example.
摘要翻译： 本公开涉及改变身体组织，特别是眼组织的机械和/或化学性质。 在具体情况下，它涉及改变或稳定角膜的形状，例如患有或具有扩张或圆锥角膜风险的受试者。 在其他具体情况下，它涉及加强遭受或面临近视眼的受试者的巩膜。 本发明使用例如对组织进行交联的可光活化化合物的光照射。
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