公开(公告)号：US12030917B2

公开(公告)日：2024-07-09

申请号：US17276399

申请日：2019-09-13

Applicant: NAGOYA INSTITUTE OF TECHNOLOGY

Inventor： Shunta Shigemura ,  Shoko Hososhima ,  Satoshi Tsunoda ,  Hideki Kandori

IPC: C07K14/405 ,  A61K38/00 ,  A61P27/02 ,  G01N33/68

CPC classification number: C07K14/405 ,  A61P27/02 ,  G01N33/68 ,  A61K38/00 ,  G01N2333/405

Abstract: An excellent photosensitivity is exhibited by a protein including, at a position or positions corresponding to one or two or more positions selected from the group made of the following (1) to (3) in a first amino acid sequence represented by SEQ ID NO: 1: (1) positions 39, 94, 98, 102, 110, 113, 114, 162, 224, 225, 230, 231, and 235, (2) positions 53, 61, 68, 74, 76, 80, 130, 137, 194, 195, 198, 200, 204, 205, 209, 210, 253, and 254, and (3) positions 46, 83, 84, 87, 90, 91, 116, 117, 120, 124, 139, 142, 143, 146, 173, 214, 216, 217, 238, 242, and 245, an amino acid residue different from that in the first amino acid sequence, and that has channel activity.

公开(公告)号：US20240301011A1

公开(公告)日：2024-09-12

申请号：US18669628

申请日：2024-05-21

Applicant: Nagoya Institute of Technology

Inventor： Shunta SHIGEMURA ,  Shoko Hososhima ,  Satoshi Tsunoda ,  Hideki Kandori

IPC: C07K14/405 ,  A61K38/00 ,  A61P27/02 ,  G01N33/68

CPC classification number: C07K14/405 ,  A61P27/02 ,  G01N33/68 ,  A61K38/00 ,  G01N2333/405

Abstract: An excellent photosensitivity is exhibited by a protein including, at a position or positions corresponding to one or two or more positions selected from the group made of the following (1) to (3) in a first amino acid sequence represented by SEQ ID NO: 1: (1) positions 39, 94, 98, 102, 110, 113, 114, 162, 224, 225, 230, 231, and 235, (2) positions 53, 61, 68, 74, 76, 80, 130, 137, 194, 195, 198, 200, 204, 205, 209, 210, 253, and 254, and (3) positions 46, 83, 84, 87, 90, 91, 116, 117, 120, 124, 139, 142, 143, 146, 173, 214, 216, 217, 238, 242, and 245, an amino acid residue different from that in the first amino acid sequence, and that has channel activity.