公开(公告)号：US10889606B2

公开(公告)日：2021-01-12

申请号：US16487848

申请日：2018-02-13

Applicant: NANJING FORESTRY UNIVERSITY

Inventor： Li Xu ,  Fuliang Cao ,  Shilong Yang

IPC: A61P39/06 ,  C07F15/02

Abstract: A method for preparing a biflavone-iron complex, includes using the amentoflavone as the ligand and the ferric ion as the central ion, the amentoflavone-iron complex is obtained by reaction, and the structure of the complex is characterized by infrared spectroscopy, UV-vis absorption spectroscopy and high resolution mass spectrometry. Meanwhile, the antitumor and antioxidant activities of the amentoflavone-iron complex are studied in the present invention. MTT method shows that the amentoflavone-iron complex has a relatively good antitumor activity, and the antitumor activity thereof is stronger than that of the amentoflavone. Pyrogallol auto-oxidation method and ABTS method show that the antioxidative activity of the amentoflavone-iron complex is stronger than that of the amentoflavone itself.

公开(公告)号：US10808001B2

公开(公告)日：2020-10-20

申请号：US16487846

申请日：2018-02-13

Applicant: NANJING FORESTRY UNIVERSITY

Inventor： Guibin Wang ,  Li Xu ,  Shilong Yang ,  Fuliang Cao

IPC: C07F15/00 ,  C07F15/06

Abstract: A method for preparing a biflavone-cobalt complex includes using the amentoflavone as the ligand and the cobalt ion as the central ion, the amentoflavone-cobalt complex is obtained by reaction, and the structure of the complex is characterized by infrared spectroscopy, UV-vis absorption spectroscopy and high resolution mass spectrometry. Meanwhile, the antitumor and antioxidant activities of the amentoflavone-cobalt complex are studied in the present invention. MTT method shows that the amentoflavone-cobalt complex has better antitumor activity, and the antitumor activity thereof is stronger than that of the amentoflavone. Pyrogallol auto-oxidation method, ABTS method and FRAP method show that the antioxidan activity of the amentoflavone-cobalt complex is stronger than that of the amentoflavone itself. The formation of the flavonoid-cobalt complex enhances the antitumor and anti-oxidation activities of the amentoflavone, and is expected to be used in the development of drugs.

公开(公告)号：US10815254B2

公开(公告)日：2020-10-27

申请号：US16487842

申请日：2018-02-13

Applicant: NANJING FORESTRY UNIVERSITY

Inventor： Fuliang Cao ,  Li Xu ,  Shilong Yang

IPC: C07F3/06

Abstract: The present invention discloses a biflavone-zinc complex, a preparation method and application thereof. In the present invention, using the amentoflavone as the ligand and the zinc ion as the central ion, the amentoflavone-zinc complex is obtained by reaction, and the structure of the complex is characterized by infrared spectroscopy, UV-vis absorption spectroscopy and high resolution mass spectrometry. Meanwhile, the antitumor and antioxidant activities of the amentoflavone-zinc complex are studied in the present invention. MTT method shows that the amentoflavone-zinc complex has better antitumor activity, and the antitumor activity thereof is stronger than that of the amentoflavone. Pyrogallol auto-oxidation method and ABTS method show that the antioxidative activity of the amentoflavone-zinc complex is stronger than that of the amentoflavone itself. The formation of the flavonoid-zinc complex enhances the antitumor and anti-oxidation activities of the amentoflavone, and is expected to be used in the development of drugs.

公开(公告)号：US10815252B2

公开(公告)日：2020-10-27

申请号：US16487845

申请日：2018-02-13

Applicant: NANJING FORESTRY UNIVERSITY

Inventor： Li Xu ,  Shilong Yang ,  Zhong Li

IPC: A61P35/00 ,  C07F1/00

Abstract: A biflavone-copper complex, a preparation method and application thereof are disclosed. The biflavone-copper complex has the following structural formula: wherein, X is NO3− or Cl−. A method of preparing the biflavone-copper complex includes the following steps: dissolving a copper salt in an alcohol and then adding into a biflavone alcoholic solution, controlling pH to 5-7; under heating and stirring, performing a reaction for 2-5 h to form a precipitate; filtering the precipitate, washing the precipitate with alcohol and water, recrystallizing the precipitate using dimethyl sulfoxide as a solvent, and drying the precipitate to obtain the biflavone-copper complex. The biflavone-copper complex is used for preparing an antitumor drug and/or an antioxidant drug.