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公开(公告)号：US20220033481A1
公开(公告)日：2022-02-03
申请号：US16755268
申请日：2017-10-11
发明人： Yafeng ZHANG , Shu WU , Fei SUN , Shuai YANG , Chuan-Chu CHOU
摘要： Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.
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公开(公告)号：US20210275590A1
公开(公告)日：2021-09-09
申请号：US17274458
申请日：2019-09-10
发明人： Yafeng ZHANG , Tailan ZHAN , Fei SUN , Jian LIU , Qing ZHANG , Shu WU
IPC分类号： A61K35/17 , C07K16/28 , A61P35/00 , C07K14/725
摘要： The present application provides single-domain antibodies targeting CD33 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune cells (such as T cells) comprising an anti-CD33 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
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