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公开(公告)号：US20190233519A1
公开(公告)日：2019-08-01
申请号：US16341034
申请日：2017-10-10
发明人： Yafeng ZHANG , Shu WU , Shuai YANG , Chuan-Chu CHOU
IPC分类号： C07K16/28 , A61K39/395 , A61K47/68 , A61P35/00 , A61K47/65
CPC分类号： C07K16/2818 , A61K39/3955 , A61K47/65 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61P31/00 , A61P35/00 , C07K16/2827 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes CTLA-4. Also provided are methods of making and using these constructs.
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公开(公告)号：US20210221891A1
公开(公告)日：2021-07-22
申请号：US16764411
申请日：2018-11-13
发明人： Yafeng ZHANG , Shu WU , Shuai YANG , Chuan-Chu CHOU
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , A61P35/00
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.
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公开(公告)号：US20200369770A1
公开(公告)日：2020-11-26
申请号：US16960521
申请日：2019-01-08
发明人： Yafeng ZHANG , Chuan-Chu CHOU , Qi PAN , Shu WU , Shuai YANG
IPC分类号： C07K16/28
摘要： Provided are multispecific, such as trispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, a second antigen binding domain comprising a first single-domain antibody, and a third antigen binding domain comprising a second single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
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公开(公告)号：US20210017279A1
公开(公告)日：2021-01-21
申请号：US17043054
申请日：2019-03-29
发明人： Wang Zhang , Shuai YANG , Shu WU , Chuan-Chu CHOU
摘要： The present application provides anti-LAG-3 constructs comprising a single-domain antibody (sdAb) that specifically recognizes LAG-3. Also provided are methods of making and using these constructs.
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公开(公告)号：US20200347135A1
公开(公告)日：2020-11-05
申请号：US16962023
申请日：2019-01-15
发明人： Yafeng ZHANG , Shu WU , Shuai YANG , Chuan-Chu CHOU
IPC分类号： C07K16/28
摘要： Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-1. Also provided are methods of making and using these constructs.
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公开(公告)号：US20240124580A1
公开(公告)日：2024-04-18
申请号：US18397363
申请日：2023-12-27
发明人： Wang ZHANG , Shu WU , Shuai YANG , Qi PAN , Chuan-Chu CHOU
CPC分类号： C07K16/2803 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K2039/505
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.
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公开(公告)号：US20220033481A1
公开(公告)日：2022-02-03
申请号：US16755268
申请日：2017-10-11
发明人： Yafeng ZHANG , Shu WU , Fei SUN , Shuai YANG , Chuan-Chu CHOU
摘要： Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.
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公开(公告)号：US20210054071A1
公开(公告)日：2021-02-25
申请号：US16958397
申请日：2018-12-28
发明人： Wang ZHANG , Shu WU , Shuai YANG , Qi PAN , Chuan-Chu CHOU
摘要： Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.
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公开(公告)号：US20230059836A1
公开(公告)日：2023-02-23
申请号：US17818942
申请日：2022-08-10
发明人： Chuan-Chu CHOU , Yafeng ZHANG , Shu WU , Zhenyu LIU , Zhongdao LI , Fangliang ZHANG
摘要： Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
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公开(公告)号：US20190202935A1
公开(公告)日：2019-07-04
申请号：US16319224
申请日：2017-07-20
发明人： Chuan-Chu CHOU , Yafeng ZHANG , Shu WU , Zhenyu LIU , Zhongdao LI , Fangliang ZHANG
CPC分类号： C07K16/46 , A61K2039/505 , A61P29/00 , A61P35/00 , A61P37/00 , C07K16/24 , C07K16/2818 , C07K16/30 , C07K2317/24 , C07K2317/31
摘要： Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
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