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公开(公告)号：US20210221891A1
公开(公告)日：2021-07-22
申请号：US16764411
申请日：2018-11-13
发明人： Yafeng ZHANG , Shu WU , Shuai YANG , Chuan-Chu CHOU
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395 , A61P35/00
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.
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公开(公告)号：US20200369770A1
公开(公告)日：2020-11-26
申请号：US16960521
申请日：2019-01-08
发明人： Yafeng ZHANG , Chuan-Chu CHOU , Qi PAN , Shu WU , Shuai YANG
IPC分类号： C07K16/28
摘要： Provided are multispecific, such as trispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, a second antigen binding domain comprising a first single-domain antibody, and a third antigen binding domain comprising a second single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
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公开(公告)号：US20230059836A1
公开(公告)日：2023-02-23
申请号：US17818942
申请日：2022-08-10
发明人： Chuan-Chu CHOU , Yafeng ZHANG , Shu WU , Zhenyu LIU , Zhongdao LI , Fangliang ZHANG
摘要： Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
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公开(公告)号：US20190202935A1
公开(公告)日：2019-07-04
申请号：US16319224
申请日：2017-07-20
发明人： Chuan-Chu CHOU , Yafeng ZHANG , Shu WU , Zhenyu LIU , Zhongdao LI , Fangliang ZHANG
CPC分类号： C07K16/46 , A61K2039/505 , A61P29/00 , A61P35/00 , A61P37/00 , C07K16/24 , C07K16/2818 , C07K16/30 , C07K2317/24 , C07K2317/31
摘要： Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.
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公开(公告)号：US20240180964A1
公开(公告)日：2024-06-06
申请号：US18286684
申请日：2022-04-19
发明人： Qingling JIANG , Yafeng ZHANG , Yanliang ZHU , Miaomiao SHI , Shu WU
IPC分类号： A61K35/17 , A61K39/00 , A61P35/00 , C07K16/28 , C12N5/0783
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/464429 , A61P35/00 , C07K16/2851 , C07K16/2896 , C12N5/0636 , A61K2239/13 , A61K2239/17 , A61K2239/21 , A61K2239/22 , A61K2239/48
摘要： An immune effector cell expressing a chimeric cytokine receptor comprising a first extracellular antigen binding domain, a first transmembrane domain, and a cytokine receptor intracellular domain; and a functional exogenous receptor comprising a second extracellular antigen binding domain, a second transmembrane domain, and an intracellular signaling domain.
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公开(公告)号：US20210277126A1
公开(公告)日：2021-09-09
申请号：US17274460
申请日：2019-09-10
发明人： Wang ZHANG , Yunlei LIU , Xiaojie TU , Chenyu SHU , Tailan ZHAN , Yun ZHANG , An TANG , Yafeng ZHANG , Shu WU , Qing ZHANG
IPC分类号： C07K16/28 , C12N5/0783 , A61P35/00 , C07K14/725 , C07K14/705
摘要： Provided are single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
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公开(公告)号：US20190233519A1
公开(公告)日：2019-08-01
申请号：US16341034
申请日：2017-10-10
发明人： Yafeng ZHANG , Shu WU , Shuai YANG , Chuan-Chu CHOU
IPC分类号： C07K16/28 , A61K39/395 , A61K47/68 , A61P35/00 , A61K47/65
CPC分类号： C07K16/2818 , A61K39/3955 , A61K47/65 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61P31/00 , A61P35/00 , C07K16/2827 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes CTLA-4. Also provided are methods of making and using these constructs.
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公开(公告)号：US20240124580A1
公开(公告)日：2024-04-18
申请号：US18397363
申请日：2023-12-27
发明人： Wang ZHANG , Shu WU , Shuai YANG , Qi PAN , Chuan-Chu CHOU
CPC分类号： C07K16/2803 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K2039/505
摘要： The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.
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公开(公告)号：US20230149461A1
公开(公告)日：2023-05-18
申请号：US17916370
申请日：2021-04-01
发明人： Zhongyuan TU , Jie LI , Yafeng ZHANG , Shu WU
CPC分类号： A61K35/17 , C12N5/0636 , A61K38/1774 , A61K35/15 , A61P37/06 , A61P35/00 , C12N2501/2302
摘要： Provided are modified therapeutic cells that overexpress an immune checkpoint ligand such as PD-L1, CD155, CD112, FGL1, galectin-9, CD47, B7H3 and B7H4, while expressing one or more Major Histocompatibility Complex (MHC) molecules. Also provided are methods of treatment using the modified therapeutic cells.
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公开(公告)号：US20220096547A1
公开(公告)日：2022-03-31
申请号：US17420657
申请日：2020-01-03
发明人： Yafeng ZHANG , Shu WU , Zhongyuan TU , Wang ZHANG , Qinghe ZHANG
IPC分类号： A61K35/17 , C07K14/255 , C12N15/63 , C12N5/0783 , C07K14/725 , C07K14/705 , C12N5/16
摘要： Provided are modified immune cells expressing a flagellin polypeptide capable of binding to a toll-like receptor. The modified immune cell further comprises an engineered receptor. Also provided are methods and pharmaceutical compositions for cancer treatment using the modified immune cells.
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