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公开(公告)号：US20210275590A1
公开(公告)日：2021-09-09
申请号：US17274458
申请日：2019-09-10
发明人： Yafeng ZHANG , Tailan ZHAN , Fei SUN , Jian LIU , Qing ZHANG , Shu WU
IPC分类号： A61K35/17 , C07K16/28 , A61P35/00 , C07K14/725
摘要： The present application provides single-domain antibodies targeting CD33 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune cells (such as T cells) comprising an anti-CD33 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
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公开(公告)号：US20210277126A1
公开(公告)日：2021-09-09
申请号：US17274460
申请日：2019-09-10
发明人： Wang ZHANG , Yunlei LIU , Xiaojie TU , Chenyu SHU , Tailan ZHAN , Yun ZHANG , An TANG , Yafeng ZHANG , Shu WU , Qing ZHANG
IPC分类号： C07K16/28 , C12N5/0783 , A61P35/00 , C07K14/725 , C07K14/705
摘要： Provided are single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
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