公开(公告)号：US20210277126A1

公开(公告)日：2021-09-09

申请号：US17274460

申请日：2019-09-10

申请人： NANJING LEGEND BIOTECH CO., LTD.

发明人： Wang ZHANG ,  Yunlei LIU ,  Xiaojie TU ,  Chenyu SHU ,  Tailan ZHAN ,  Yun ZHANG ,  An TANG ,  Yafeng ZHANG ,  Shu WU ,  Qing ZHANG

IPC分类号： C07K16/28 ,  C12N5/0783 ,  A61P35/00 ,  C07K14/725 ,  C07K14/705

摘要： Provided are single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.