公开(公告)号：US11845708B2

公开(公告)日：2023-12-19

申请号：US17486807

申请日：2021-09-27

Applicant: NANJING TECH UNIVERSITY

Inventor： Xiaoqiang Chen ,  Tingwen Wei ,  Jing Wang ,  Yanyan Wang

IPC: C07C227/04 ,  C07D209/20 ,  C07D235/22 ,  C07D403/06

CPC classification number: C07C227/04 ,  C07D209/20 ,  C07D235/22 ,  C07D403/06

Abstract: The present disclosure provides a method for photocleavage of an amide bond, the method has mild reaction conditions and can realize the cleavage of amide bonds by using light. The method comprises the following steps: subjecting 2,4-dinitrofluorobenzene to a reaction with an amino group of a substance represented by structural formula I with an α-amino acid at the end to produce a compound 1 represented by structural formula II; then under light irradiation, subjecting the compound 1 to a cleavage reaction of amide bond;




Wherein, R1 is the side chain group of α-amino acid; R2 is: aryl, aliphatic hydrocarbon, —CH(R)—COOH or polypeptide.