公开(公告)号：US20240000940A1

公开(公告)日：2024-01-04

申请号：US18039728

申请日：2021-11-30

申请人： NANOBIOTIX S.A.

发明人： LAURENT LEVY ,  CÉLINE BERJAUD ,  ALEXANDRA MADEIRA ,  JULIE MARILL ,  MARIE-EDITH MEYRE

IPC分类号： A61K41/00 ,  A61P35/00 ,  A61N5/10 ,  A61K33/42 ,  B82Y5/00

CPC分类号： A61K41/0038 ,  A61P35/00 ,  A61N5/1001 ,  A61K33/42 ,  B82Y5/00 ,  A61N2005/1098

摘要： The invention concerns a particle and a composition comprising particles and their use in oncology. Specifically, the particles are porous, high-Z and carbon-free particles having internal pores, of longest dimension of at least 0.5 nm, and are for use in altering or destroying target cells in a mammal when said cells are exposed to ionizing radiation.
The present invention also provides a porous, high-Z and carbon-free particle wherein at least part of the porous structure of the particle is occupied by at least one therapeutic agent which is preferably for use in oncology.

公开(公告)号：US20220212008A1

公开(公告)日：2022-07-07

申请号：US17697976

申请日：2022-03-18

申请人： NANOBIOTIX S.A.

发明人： MARIE-EDITH MEYRE ,  AGNÈS POTTIER ,  LAURENT LEVY

IPC分类号： A61N1/36 ,  A61P25/00 ,  A61K41/00 ,  A61N2/00

摘要： The present invention relates to the medical field, in particular to the treatment of neurological disorders. More specifically the present invention relates to a nanoparticle or nanoparticles' aggregate for use in prevention or treatment of a neurological disease or at least one symptom thereof in a subject when the nanoparticle or nanoparticles' aggregate is exposed to an electric field, wherein the nanoparticle's or nanoparticles' aggregate's material is selected from a conductor material, a semiconductor material, an insulator material with a dielectric constant εijk equal to or above 200, and an insulator material with a dielectric constant εijk equal to or below 100. It further relates to compositions and kits comprising such nanoparticles and/or nanoparticles' aggregates as well as to uses thereof.