公开(公告)号：US20230181705A1

公开(公告)日：2023-06-15

申请号：US17999335

申请日：2021-05-17

Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY

Inventor： Guangjun NIE ,  Ruifang ZHAO ,  Long CHEN ,  Hao QIN ,  Yuliang ZHAO

IPC: A61K39/00 ,  A61K39/39 ,  A61K9/50 ,  A61K9/48 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K39/39 ,  A61K9/5068 ,  A61K9/4866 ,  A61P35/00 ,  A61K2039/55594 ,  A61K2039/55516 ,  A61K2039/6093

Abstract: A tumor vaccine, a preparation method therefor, and use of the tumor vaccine thereof. A pharmaceutical combination with a first membrane component having a membrane derived from the inner membrane of bacteria, the pharmaceutical combination further includes components derived from other organisms than the bacteria. A method for enhancing an uptake of a target antigen by an immune cell, activating an immune cell, enhancing an innate immunity and/or a specific immune response and/or preventing and/or treating a tumor. A tumor vaccine for preventing postoperative recurrence of cancer.

公开(公告)号：US20190240248A1

公开(公告)日：2019-08-08

申请号：US16208103

申请日：2018-12-03

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY

Inventor： Hao YAN ,  Qiao JIANG ,  Suping LI ,  Baoquan DING ,  Guangjun NIE

IPC: A61K31/7088 ,  A61K9/00 ,  A61K47/26 ,  C12N7/00 ,  A61K9/51 ,  C12N15/115 ,  A61P35/00

CPC classification number: A61K31/7088 ,  A61K9/0019 ,  A61K9/51 ,  A61K47/26 ,  A61P35/00 ,  B82Y5/00 ,  B82Y40/00 ,  C12N7/00 ,  C12N15/115 ,  C12N2310/16 ,  C12N2795/00022 ,  C12N2795/00032 ,  C12N2795/00042

Abstract: In certain embodiments, the present invention provides a DNA nanostructure nanorobot comprising: a single stranded DNA scaffold strand of about 5,000 to 10,000 bases in length; a plurality of staple strands of DNA, wherein each staple strands are about 20 to 40 bases in length, wherein each staple strand has a unique sequence and is hybridized to a specific position on the DNA scaffold strand, wherein the plurality of staple strands hybridized to the DNA scaffold form a sheet having a top surface and a bottom surface; and one or more fastener strands of DNA, wherein the one or more fastener strands of DNA is capable of fastening the sheet into an origami structure.