中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

25 records (took 0.018 seconds)

    ANTIGEN COMPOSITION, PREPARATION METHOD AND USE THEREOF, AND TUMOR VACCINE
    2.
    发明申请
    ANTIGEN COMPOSITION, PREPARATION METHOD AND USE THEREOF, AND TUMOR VACCINE 有权
    抗原组合物，制备方法及其用途及肿瘤疫苗

    公开(公告)号：US20150093415A1

    公开(公告)日：2015-04-02

    申请号：US14394986

    申请日：2013-02-04

    Applicant: National Center for Nanoscience and Technology

    Inventor： Guangjun Nie ,  Xin Tian ,  Motao Zhu

    IPC: A61K39/00 ,  C12N5/0784

    CPC classification number: A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  C12N5/0639 ,  C12N2501/052 ,  C12N2501/22 ,  C12N2501/2304

    Abstract: The present invention provides a preparation method of an antigen composition. The preparation method comprises the following steps: (1) obtaining a tumor antigen protein; (2) making the tumor antigen protein into contact with an immature dendritic cell; (3) inducing the immature dendritic cell in contact with the tumor antigen into a mature dendritic cell; and (4) separating a cell vesicle of the mature dendritic cell. The present invention further provides an antigen composition obtained through the preparation method and the application thereof in preparing a tumor vaccine.

    Abstract translation: 本发明提供抗原组合物的制备方法。 制备方法包括以下步骤：（1）获得肿瘤抗原蛋白; （2）使肿瘤抗原蛋白与未成熟树突状细胞接触; （3）将与肿瘤抗原接触的未成熟树突状细胞诱导成成熟树突状细胞; 和（4）分离成熟树突状细胞的细胞囊泡。 本发明还提供通过制备方法获得的抗原组合物及其在制备肿瘤疫苗中的应用。

    Implantable flexible neural microelectrode comb, and preparation method and implantation method therefor
    4.
    发明授权
    Implantable flexible neural microelectrode comb, and preparation method and implantation method therefor 有权

    公开(公告)号：US11369302B2

    公开(公告)日：2022-06-28

    申请号：US16471545

    申请日：2017-02-06

    Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINA

    Inventor： Ying Fang ,  Jinfen Wang ,  Shouliang Guan ,  Mingde Du ,  Liang Zou

    IPC: H01K3/02 ,  A61B5/291 ,  H05K1/02 ,  H05K1/09 ,  H05K1/11 ,  H05K3/00 ,  H05K3/14 ,  H05K3/28 ,  A61B5/24

    Abstract: Disclosed are an implantable flexible neural microelectrode comb, and a preparation method and implantation method therefor. The flexible neural microelectrode comb is mainly composed of a flexible substrate layer (1), a flexible insulation layer (2), and a metal connection wire layer (3) arranged between the flexible substrate layer (1) and the flexible insulation layer (2); the flexible neural microelectrode comb comprises a filament structure (4), a mesh structure (5), a plane structure (6) and a bonding pad area (7) connected in sequence; electrode sites (8) are arranged on the filament structure (4); bonding pads are arranged on the bonding pad area (7); the metal connection wire layer (3) is composed of metal connection wires connecting the electrode sites (8) and the bonding pads; and the flexible insulation layer (2) is not arranged on the surfaces of the electrode sites (8) and the bonding pads. The prepared flexible neural microelectrode comb has a structure gradually changing from a filament to a mesh to a plane structure, thus improving mechanical stability during a deformation process. The mechanical properties of the implantable flexible neural microelectrode comb match brain tissue, the implantation footprint is small, an inflammatory response of the brain is avoided, and electrophysiological signals in the brain can be stably tracked and measured in a multi-site manner for a long time.

    Filament positioning system and filament positioning method
    6.
    发明授权
    Filament positioning system and filament positioning method 有权

    公开(公告)号：US10607805B2

    公开(公告)日：2020-03-31

    申请号：US15834152

    申请日：2017-12-07

    Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINA

    Inventor： Xixue Hu ,  Hongbo Guo ,  Dongliang Wang ,  Yaling Gan ,  Xiaohui Xu

    IPC: H04N9/47 ,  H04N7/18 ,  H01J37/067 ,  G06T7/73 ,  H01J37/244

    Abstract: Disclosed are a filament positioning system and a filament positioning method. The filament positioning system includes a bottom plate, a first positioning regulating mechanism and a second positioning regulating mechanism, wherein the first positioning regulating mechanism is configured to conduct positioning regulation of a position of a filament seat on the bottom plate, so that filament seats of different models can be fixed to the bottom plate, and the second positioning regulating mechanism is configured to conduct positioning regulation on the filament; and a detection module configured to collect and display position information of a filament tip and the filament seat, wherein the first positioning regulating mechanism and the second positioning regulating mechanism correspondingly regulate positions of the filament seat and the filament tip according to the position information.

    DNA NANOVACCINE, PREPARATION METHOD THEREFOR AND USE THEREOF
    7.
    发明公开
    DNA NANOVACCINE, PREPARATION METHOD THEREFOR AND USE THEREOF 审中-公开

    公开(公告)号：US20230355766A1

    公开(公告)日：2023-11-09

    申请号：US17774695

    申请日：2020-09-04

    Applicant: NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY

    Inventor： Baoquan Ding ,  Shaoli Liu ,  Qiao Jiang

    IPC: A61K39/00 ,  A61P37/04

    CPC classification number: A61K39/464499 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/55561 ,  B82Y5/00

    Abstract: Provided are a DNA nanovaccine, a preparation method therefor and the use thereof. The DNA nanovaccine comprises a DNA nanostructure, a tumor antigen polypeptide-DNA complex and an immunologic adjuvant, and the immunologic adjuvant comprises a double-stranded RNA immunologic adjuvant and/or a CpG immunologic adjuvant. In the present invention, a nanostructure is constructed, wherein the nanostructure is assembled from a DNA template, a DNA chain for assisting in folding and a capture DNA chain. By hybridizing the capture DNA chain with a functional component, the precise positioning and assembling of a tumor antigen molecule and an immunologic adjuvant molecule on the surface of the DNA self-assembled nanostructure is realized; in addition, a controllable DNA molecule “switch” is designed on one side of the tubular DNA nanostructure, which switch can respond to the acid environment of an endosome after entering an antigen-presenting cell, and open the tubular structure responsively to release the tumor antigen and the immunologic adjuvant molecule. The nanostructure has a tumor antigen-specific immunostimulatory effect and is a tumor vaccine used for the immunotherapy and prevention of various types of malignant tumors.

Patent Agency Ranking