公开(公告)号：US20240094126A1

公开(公告)日：2024-03-21

申请号：US17768198

申请日：2020-11-04

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Masanobu IWANAGA

IPC: G01N21/64 ,  B82Y30/00 ,  G01N33/553 ,  G01N33/58

CPC classification number: G01N21/645 ,  B82Y30/00 ,  G01N21/6428 ,  G01N33/553 ,  G01N33/582 ,  G01N2021/7763

Abstract: The present invention has for its object to provide an inspection chip using a metasurface for detection of biomolecules by a fluorescence detection method.
The inspection chip comprises a first substrate having a metasurface, and a second substrate positioned in opposition to the first substrate and having a microchannel, as shown in FIG. 1. The metasurface includes a gap for efficient immobilization of the biomolecules to be detected, and induces or develops fluorescence enhancement in a region including a wavelength range of fluorescence emitted by the biomolecules to be detected. The second substrate is formed of a material transparent to visible light or near infrared light, and the fluorescence resonates between the first substrate and second substrate.