公开(公告)号：US10046893B2

公开(公告)日：2018-08-14

申请号：US15484812

申请日：2017-04-11

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Mojra Janta ,  Xuyen Dai Hoa ,  Matthias Geissler ,  Teodor Veres

IPC: B65D73/00 ,  B65D65/40 ,  B65B9/02 ,  B65D75/36 ,  B01L3/00 ,  B65D75/32 ,  B81C1/00 ,  B29C65/76 ,  B29C65/00 ,  B29L31/00

Abstract: A patterned thermoplastic elastomer (TPE) film for fabricating a liquid-filled blister, has a blister-sized cavity in fluid communication with a microfluidic channel via a gating region. The gating region is defined by a relief pattern that has at least one of the following: at least 5 separate compartments defined by respective recesses in the first side, each of the recesses bounded by walls that separate the compartments from each other, the recess, or the channel; at least 5 walls defined by the patterning of the first side, the walls separating a plurality of compartments from each other, the recess, or the channel, wherein the walls have a mean thickness that is less than a mean height, and each pair of walls has a mean separation greater than twice the mean thickness; an array of separate compartments bounded by walls defined by the patterning of the first side that collectively define a polygonal regular planar tiling with at least 50% of the surface area of the gating region being open spaces; and a focusing region in fluid communication with the cavity, and a seal region having at least one wall defined by patterning of the film, wherein the at least one wall separates the focusing region from the seal region, and a shape of the at least one wall tapers the focusing region towards the seal region.