公开(公告)号：US11478754B2

公开(公告)日：2022-10-25

申请号：US16725183

申请日：2019-12-23

Applicant: National Research Council of Canada ,  The Royal Institution for the Advancement of Learning/McGill University

Inventor： Kebin Li ,  Teodor Veres ,  Tohid Fatanat Didar ,  Maryam Tabrizian

IPC: B01D63/08 ,  B01D69/10 ,  B01D65/02 ,  F04B43/04 ,  F04B43/12 ,  F04B53/10 ,  F04B43/14

Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.

公开(公告)号：US20220221402A1

公开(公告)日：2022-07-14

申请号：US17681802

申请日：2022-02-27

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Ryan Denomme ,  Lidija Malic ,  Daniel Brassard ,  Keith Morton ,  Teodor Veres

IPC: G01N21/552 ,  B01L3/00

Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

公开(公告)号：US20240342708A1

公开(公告)日：2024-10-17

申请号：US18610057

申请日：2024-03-19

Applicant: National Research Council of Canada

Inventor： Ryan Denomme ,  Lidija Malic ,  Daniel Brassard ,  Keith Morton ,  Teodor Veres

IPC: B01L3/00 ,  G01N21/552 ,  G01N33/543

CPC classification number: B01L3/502715 ,  B01L3/502746 ,  B01L3/502784 ,  B01L3/502792 ,  G01N21/554 ,  G01N33/54386 ,  B01L2300/0645 ,  B01L2300/0663 ,  G01N2201/023 ,  G01N2201/061

Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

公开(公告)号：US11867320B2

公开(公告)日：2024-01-09

申请号：US16970520

申请日：2019-03-04

Applicant: National Research Council of Canada

Inventor： Kebin Li ,  Keith Morton ,  Teodor Veres

IPC: F16K99/00 ,  B01L3/00

CPC classification number: F16K99/0025 ,  F16K99/0015 ,  B01L3/502738 ,  B01L2200/12 ,  B01L2300/123 ,  B01L2400/0487 ,  B01L2400/0655 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0084

Abstract: In a polymeric microfluidic valve, an adhesion control surface with discrete micro- or nano-scale structured surfaces are separated by fluid filled voids at an interface between an elastomeric membrane seals against a substrate layer. The structured surfaces reduce adhesion between the membrane layer and the substrate layer and prevent permanent bonding, while at the same time providing a good balance of adhesion at the valve seat to provide a sealing engagement. Microstructured adhesion control surfaces on and around valve bodies permit opening the valve, by reducing contact surface area.

公开(公告)号：US11661469B2

公开(公告)日：2023-05-30

申请号：US16651018

申请日：2018-09-25

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Lidija Malic ,  Xuefeng Zhang ,  Keith Morton ,  Teodor Veres

IPC: C08F290/06 ,  C08F222/10 ,  C08J7/18 ,  C08K3/08 ,  G03F7/004 ,  G03F7/027 ,  G03F7/028 ,  C08J7/044 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/00

CPC classification number: C08F290/062 ,  C08F222/102 ,  C08J7/044 ,  C08J7/18 ,  C08K3/08 ,  G03F7/0043 ,  G03F7/028 ,  G03F7/0275 ,  B82Y30/00 ,  B82Y40/00 ,  C08J2333/08 ,  C08K2003/0831 ,  C08K2201/011 ,  G03F7/0037

Abstract: Disclosed is a method of preparing polymer film-metal composites and uses of such composites. The metal can be in the form of a nanoparticle or a film. The methods comprise depositing on a surface, a composition comprising: a cationic metal precursor; a polymer film precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite on the surface.

公开(公告)号：US11958048B2

公开(公告)日：2024-04-16

申请号：US17681802

申请日：2022-02-27

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Ryan Denomme ,  Lidija Malic ,  Daniel Brassard ,  Keith Morton ,  Teodor Veres

IPC: B01L3/00 ,  G01N21/552 ,  G01N33/543

CPC classification number: B01L3/502715 ,  B01L3/502746 ,  B01L3/502784 ,  B01L3/502792 ,  G01N21/554 ,  G01N33/54386 ,  B01L2300/0645 ,  B01L2300/0663 ,  G01N2201/023 ,  G01N2201/061

Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

公开(公告)号：US10369566B2

公开(公告)日：2019-08-06

申请号：US14989320

申请日：2016-01-06

Applicant: National Research Council of Canada

Inventor： Emmanuel Roy ,  Teodor Veres

IPC: B01L3/00 ,  B29L9/00 ,  B32B3/30 ,  B32B7/02 ,  B32B27/30 ,  B29C71/02 ,  B32B27/28 ,  B32B25/04 ,  B32B25/14 ,  B29C41/04 ,  B29C59/02 ,  B29C65/02 ,  C08J5/18 ,  B29K19/00

Abstract: A composition made of at least 60 wt. % of a thermoplastic elastomer resin and additives that are solid at least from 0-50° C., that has a Shore A hardness that is less than about 50 bears a patterned surface, the pattern comprising at least one microfluidic channel having a cross-sectional dimension smaller than 100 microns is a substrate for forming a microfluidic device. The chief advantages of such compositions are: its ability to bond in a sealing manner to smooth surfaces of many different compositions, its ease of manufacture and microstructure patterning, and its general impermeability to liquids.

公开(公告)号：US10046893B2

公开(公告)日：2018-08-14

申请号：US15484812

申请日：2017-04-11

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Mojra Janta ,  Xuyen Dai Hoa ,  Matthias Geissler ,  Teodor Veres

IPC: B65D73/00 ,  B65D65/40 ,  B65B9/02 ,  B65D75/36 ,  B01L3/00 ,  B65D75/32 ,  B81C1/00 ,  B29C65/76 ,  B29C65/00 ,  B29L31/00

Abstract: A patterned thermoplastic elastomer (TPE) film for fabricating a liquid-filled blister, has a blister-sized cavity in fluid communication with a microfluidic channel via a gating region. The gating region is defined by a relief pattern that has at least one of the following: at least 5 separate compartments defined by respective recesses in the first side, each of the recesses bounded by walls that separate the compartments from each other, the recess, or the channel; at least 5 walls defined by the patterning of the first side, the walls separating a plurality of compartments from each other, the recess, or the channel, wherein the walls have a mean thickness that is less than a mean height, and each pair of walls has a mean separation greater than twice the mean thickness; an array of separate compartments bounded by walls defined by the patterning of the first side that collectively define a polygonal regular planar tiling with at least 50% of the surface area of the gating region being open spaces; and a focusing region in fluid communication with the cavity, and a seal region having at least one wall defined by patterning of the film, wherein the at least one wall separates the focusing region from the seal region, and a shape of the at least one wall tapers the focusing region towards the seal region.

公开(公告)号：US11753485B2

公开(公告)日：2023-09-12

申请号：US16651067

申请日：2018-09-25

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Lidija Malic ,  Xuefeng Zhang ,  Keith Morton ,  Teodor Veres

IPC: C08F2/01 ,  C08F222/10 ,  C08F2/44 ,  C08F2/48 ,  C08K3/08 ,  C08K5/053 ,  C12Q1/686 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C08F2/01 ,  C08F2/44 ,  C08F2/48 ,  C08F222/102 ,  C08K3/08 ,  C08K5/053 ,  C12Q1/686 ,  B82Y30/00 ,  B82Y40/00 ,  C08K2003/0831 ,  C08K2201/011

Abstract: The present application relates to polymer microparticle-metal nanoparticle composites, to methods of preparing polymer microparticle-metal nanoparticle composites and to uses of such composites. The methods comprise introducing into a microfluidic device, a composition comprising: a cationic metal nanoparticle precursor; a polymer microparticle precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite.

公开(公告)号：US11675183B2

公开(公告)日：2023-06-13

申请号：US17123233

申请日：2020-12-16

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  BANK OF CANADA

Inventor： Daniel Brassard ,  Lidija Malic ,  Keith J. Morton ,  Teodor Veres ,  Charles D. MacPherson ,  Theodoros Garanzotis

IPC: B42D25/29 ,  G02F1/01 ,  G02B26/02 ,  G02B1/00 ,  B42D25/405 ,  B82Y20/00 ,  B82B1/00 ,  B42D25/36 ,  G06Q30/018 ,  G02F1/17

CPC classification number: G02B26/026 ,  B42D25/29 ,  B42D25/36 ,  B42D25/405 ,  B82B1/003 ,  B82Y20/00 ,  G02B1/005 ,  G02F1/0128 ,  G06Q30/0185 ,  G02B2207/101 ,  G02F1/172 ,  G02F2201/38

Abstract: A security device that exhibits at least one dynamic response upon change of orientation of the security device with respect to gravity, wherein the security device includes a hollow capsule completely filled with a liquid and one or more microscopic elements. In addition, the dynamic response continues after cessation of the change of orientation with respect to gravity. The dynamic response includes a transition of the one or more microscopic elements from substantial mechanical equilibrium to non-equilibrium upon action of the change of orientation with respect to gravity and back to substantial mechanical equilibrium after cessation of the change of orientation with respect to gravity. During the dynamic response, the one or more microscopic elements undergo at least one of a rotational motion and a translational motion relative to the liquid.