公开(公告)号：US20170315126A1

公开(公告)日：2017-11-02

申请号：US15521531

申请日：2015-09-03

Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY

Inventor： Takashi TAKAHASHI ,  Tomoya YAMAGUCHI

IPC: G01N33/574 ,  C07K14/705 ,  C12N9/12

CPC classification number: G01N33/57423 ,  C07K14/705 ,  C07K14/71 ,  C12N9/12 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y207/10001 ,  G01N33/57496 ,  G01N2333/705 ,  G01N2333/71 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2800/52

Abstract: Provided is a method for screening a compound that can specifically suppress the formation of caveolae of cancer cells and can inhibit the activity of various RTKs using a single compound all at once. A method for screening a compound specifically suppressing the formation of caveolae of cancer cells wherein the screening method includes a step for bringing a test compound into contact with a system capable of detecting suppression of the binding of Cavin-1 and CAV1 and a step for selecting a compound having activity to suppress the binding of Cavin-1 and CAV1.