公开(公告)号：US20160004932A1

公开(公告)日：2016-01-07

申请号：US14769868

申请日：2014-02-24

Applicant: NEC CORPORATION

Inventor： Maki SANO ,  Yoshiko YOSHIHARA ,  Toru SANO

IPC: G06K9/62 ,  G06K9/46 ,  G06T11/20 ,  G06T7/00

CPC classification number: G06K9/6201 ,  G06F19/00 ,  G06F19/321 ,  G06K9/0014 ,  G06K9/00369 ,  G06K9/3233 ,  G06K9/46 ,  G06T7/0014 ,  G06T7/74 ,  G06T11/20 ,  G06T11/206 ,  G06T2207/30024

Abstract: When making a diagnosis by synthetically taking into account the information obtained by preparing a plurality of samples using different staining methods or the like and sequentially observing the samples, a diagnostician must remember information about the plurality of samples.The present invention includes image storage means for storing a reference image obtained by photographing a predetermined stained sample of and a comparison image obtained by photographing another stained sample of substantially identical biological tissues, partial image creation means for detecting a structure of the biological tissue from the reference image, cutting out from the comparison image a partial image that contains the structure detected, and storing into partial image storage means the partial image in association with the structure and the comparison image, image output means for outputting a result image that includes the reference image and the partial image, and the partial image storage means.

Abstract translation: 当通过综合考虑通过使用不同染色方法等制备多个样品而获得的信息并依次观察样品进行诊断时，诊断者必须记住关于多个样品的信息。 本发明包括图像存储装置，用于存储通过拍摄预定的染色样品获得的参考图像和通过拍摄基本上相同的生物组织的另一染色样本获得的比较图像;部分图像创建装置，用于从 参考图像，从所述比较图像中切出包含检测到的结构的部分图像，并且将部分图像存储装置存储为与所述结构和所述比较图像相关联的部分图像;图像输出装置，用于输出包括所述参考的结果图像 图像和部分图像以及部分图像存储装置。

公开(公告)号：US20220404363A1

公开(公告)日：2022-12-22

申请号：US17774395

申请日：2020-11-02

Applicant: NEC CORPORATION ,  UNIVERSITY OF THE RYUKYUS

Inventor： Yoshiko YOSHIHARA ,  Takuya FUKUSHIMA ,  Yuetsu TANAKA ,  Hiroaki MASUZAKI ,  Kennosuke KARUBE ,  Naoki IMAIZUMI

IPC: G01N33/569 ,  G01N33/68

Abstract: As a technique enabling to simply and accurately diagnose human T cell leukemia virus type 1 (HTLV-1) related disease, there is provided a diagnostic method for an HTLV-1 related disease based on an amount of tumor necrosis factor receptor 2 (TNFR2) in a blood sample taken from a subject, wherein (1) it is determined based on an increase of the amount of TNFR2 that the subject suffers from, or is likely to develop, the HTLV-1 related disease; and/or (2) it is determined based on a decrease of the amount of TNFR2 that the subject is in remission, or is likely to be in remission, of the HTLV-1 related disease.

公开(公告)号：US20160300345A1

公开(公告)日：2016-10-13

申请号：US15100898

申请日：2014-12-05

Applicant: NEC CORPORATION

Inventor： Yoshiko YOSHIHARA

IPC: G06T7/00 ,  G06K9/46 ,  G01N33/68

CPC classification number: G06T7/0012 ,  G01N33/6875 ,  G06K9/00134 ,  G06K9/3233 ,  G06K9/46 ,  G06K9/4652 ,  G06T2207/30004

Abstract: Luminance calculation means 81 calculates luminance of a cell nucleus extracted from an antinuclear antibody image of a designated dilution ratio. Titer prediction means 82 predicts an antinuclear antibody titer, using a staining pattern specified from a staining form of the cell nucleus and the luminance at at least one dilution ratio.

Abstract translation: 亮度计算装置81计算从指定稀释比例的抗核抗体图像提取的细胞核的亮度。 滴度预测装置82使用从细胞核的染色形式指定的染色图案和至少一个稀释比的亮度来预测抗核抗体滴度。

公开(公告)号：US20220137050A1

公开(公告)日：2022-05-05

申请号：US17429206

申请日：2020-02-06

Applicant: NEC CORPORATION

Inventor： Yoshiko YOSHIHARA ,  Takuya FUKUSHIMA ,  Megumi MIYARA

IPC: G01N33/569

Abstract: As a technique enabling to simply and accurately diagnose human T cell leukemia virus type 1 (HTLV-1) related disease, there is provided a diagnostic method for an HTLV-1 related disease, comprising the steps of: measuring the amount of a marker protein in a blood sample taken from a subject, wherein the marker protein is at least one selected from the proteins listed in Tables 1 and 2; and, if a measured value is a predetermined reference value or more or the predetermined reference value or less, determining that the subject suffers from the HTLV-1 related disease or determining that the subject is in remission of the HTLV-1 related disease.

公开(公告)号：US20210391031A1

公开(公告)日：2021-12-16

申请号：US17281707

申请日：2019-11-20

Applicant: NEC CORPORATION

Inventor： Brandon MALONE ,  Kousuke ONOUE ,  Yoshiko YOSHIHARA

IPC: G16B20/20 ,  G16B20/30 ,  G16B30/10 ,  G16B40/20

Abstract: A method of ranking epitopes derived from neoantigens as targets for personalized immunotherapy includes collecting candidate epitopes based on patient data of a cancer patient. A set of scores are calculated for each of the candidate epitopes, each of the scores in a respective one of the sets for a respective one of the candidate epitopes representing an independent measure of a likelihood of the respective one of candidate epitopes to elicit an immune response in the cancer patient. The scores in each of the sets of scores are combined into a single score for each of the candidate epitopes. The single scores for the candidate epitopes in each case reflect an overall likelihood of eliciting the immune response in the patient. The candidate epitopes are ranked using the single scores for the immunotherapy.

公开(公告)号：US20210033599A1

公开(公告)日：2021-02-04

申请号：US17044427

申请日：2019-04-25

Applicant: NEC CORPORATION ,  NATIONAL CANCER CENTER

Inventor： Tomoharu KIYUNA ,  Yoshiko YOSHIHARA ,  Hiroyasu SAIGA ,  Noriko MOTOI ,  Hiroshi YOSHIDA ,  Yuichiro OHE ,  Takashi KOHNO

IPC: G01N33/534 ,  C12Q1/6886

Abstract: An information processing apparatus (2000) extracts a histomorphological feature of a tissue included in pathological image data (10). The information processing apparatus (2000) generates prediction data (30) based on the extracted histomorphological feature. The prediction data (30) indicates one or more of a prediction relating to an effect of a cancer therapeutic drug on a target patient and a prediction of a side effect of the cancer therapeutic drug on the target patient.