公开(公告)号：US20210005281A1

公开(公告)日：2021-01-07

申请号：US16976808

申请日：2018-09-28

Applicant: NEC Corporation ,  OSAKA UNIVERSITY

Inventor： Masataka KIKUCHI ,  Akihiro NAKAYA

IPC: G16B20/50 ,  G16H50/70 ,  G16B50/00

Abstract: The present invention provides a new gene mutation assessment system which makes it possible, even when a gene mutation has considered to be apparently not associated with a trait from mutation information at a single position, to pick the gene mutation as a gene mutation candidate showing an association with the trait. The gene mutation assessment device (10) of the present invention includes a communication unit (19) that is capable of communicating a database DB, an assessment target mutation information acquisition unit (11) that acquires mutation information of a common gene mutation in a sample group showing a common trait as mutation information of an assessment target mutation, a score assignment unit (12) that assigns a first score showing an association with a trait of the DB information to the assessment target mutation based on the DB information, a score determination unit (13) that compares the first score with an association threshold and determines the assessment target mutation as a re-scoring target when the first score is less than the association threshold, a region mutation information acquisition unit (14) that acquires, as region mutation information, a gene mutation in an associated region with respect to a re-scoring target assessment target mutation based on the DB information, a score re-assignment unit (15) that assigns a second score weighted to the first score to the re-scoring target assessment target mutation based on the region mutation information, and an assessment score determination unit (16) that determines the second score as an assessment score of the re-scoring target assessment target mutation.

公开(公告)号：US20240290426A1

公开(公告)日：2024-08-29

申请号：US18569733

申请日：2021-06-14

Applicant: NEC Corporation ,  OSAKA UNIVERSITY

Inventor： Masataka KIKUCHI ,  Kenichi KAMIJO ,  Yasuto FUSHIMI ,  Kaori KOBAYASHI

IPC: G16B20/50

CPC classification number: G16B20/50

Abstract: A genetic characteristic estimation device (2000) acquires genetic mutation information (30) and position information (40). The genetic mutation information (30) indicates information regarding a genetic mutation in a deoxyribonucleic acid (DNA) sequence of a target cell (20) obtained from a target organism (10). In the position information (40), a position on the DNA sequence is associated with the type of a cell or the type of an organ. The genetic characteristic estimation device (2000) determines a genetic mutation at the position associated with the type of the target cell (20) or the type of an organ including the target cell (20) in the position information (40) from among genetic mutations indicated by the genetic mutation information (30), and computes a genetic characteristic index value representing a genetic characteristic of the target organism (10) based on a characteristic of the determined genetic mutation.

公开(公告)号：US20240371488A1

公开(公告)日：2024-11-07

申请号：US18288746

申请日：2021-04-28

Applicant: NEC CORPORATION ,  OSAKA UNIVERSITY

Inventor： Masataka KIKUCHI ,  Yasushi MATSUMURA ,  Kenichi KAMIJO ,  Yasuto FUSHIMI ,  Kaori KOBAYASHI

IPC: G16H20/10 ,  G16H70/40

Abstract: A medicine recommendation apparatus (2000) acquires disease information (20), gene mutation information (30), and current medication information (40). The disease information (20) is information regarding a disease that a subject suffers from. The gene mutation information (30) is information regarding a gene mutation of the subject. The current medication information (40) is information regarding a medicine that the subject is using. The medicine recommendation apparatus (2000) generates candidate medicine information (10) by using the disease information (20), the gene mutation information (30), and the current medication information (40). The candidate medicine information (10) is information regarding a candidate for a medicine use of which can be recommended to the subject or which can be prescribed to the subject.

公开(公告)号：US20230210441A1

公开(公告)日：2023-07-06

申请号：US17928855

申请日：2020-06-01

Applicant: NEC CORPORATION ,  OSAKA UNIVERSITY

Inventor： Masataka KIKUCHI ,  Yasusi MATSUMURA ,  Kaori KOBAYASHI ,  Kenichi KAMIJO ,  Yasuto FUSHIMI

IPC: A61B5/00

CPC classification number: A61B5/4088 ,  A61B5/4064 ,  A61B5/743

Abstract: A brain image analysis apparatus (2000) acquires input data (40) including a structural brain image (42) and a functional brain image (44) for a subject (10). The brain image analysis apparatus (2000) obtains analysis data (20) by inputting the input data (40) into an analysis model (2020). The analysis model (2020) has been trained in advance so as to output the analysis data (20) representing information about brain dysfunction in response to an input of the input data (40). The brain image analysis apparatus (2000) outputs, based on the analysis data (20), output data (30) representing information about the brain dysfunction of the subject (10).