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公开(公告)号：US20200377487A1
公开(公告)日：2020-12-03
申请号：US16711521
申请日：2019-12-12
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： C07D405/14 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/12 , A61K31/496 , A61K45/06 , C07D403/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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公开(公告)号：US20190241546A1
公开(公告)日：2019-08-08
申请号：US16135428
申请日：2018-09-19
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： C07D405/14 , A61K45/06 , C07D405/04 , C07D403/14 , C07D401/14 , A61K31/496 , C07D405/12 , C07D231/56 , C07D403/12 , C07D401/12
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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公开(公告)号：US09255087B2
公开(公告)日：2016-02-09
申请号：US14534617
申请日：2014-11-06
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： C07D405/12 , A61K31/497 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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公开(公告)号：US20180289672A1
公开(公告)日：2018-10-11
申请号：US16013019
申请日：2018-06-20
IPC分类号： A61K31/416 , C07D231/56 , A61K31/496 , C07D401/12 , A61K31/454 , C07D405/12 , A61K31/5377 , A61K45/06 , C07D295/155 , C07D295/185 , C07D403/14 , C07D403/12 , C07D401/14 , C12N9/12
CPC分类号： A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D295/155 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C12N9/12 , C12Y207/10001
摘要： The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
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公开(公告)号：US09616059B2
公开(公告)日：2017-04-11
申请号：US14971372
申请日：2015-12-16
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： A61K31/496 , A61K45/06 , C07D405/12 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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6.发明授权Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors 有权三环吡咯衍生物，其制备方法及其作为激酶抑制剂的用途公开(公告)号：US09309253B2
公开(公告)日：2016-04-12
申请号：US14609534
申请日：2015-01-30
发明人： Marina Caldarelli , Mauro Angiolini , Italo Beria , Maria Gabriella Brasca , Francesco Casuscelli , Roberto D'Alessio , Andrea Lombardi Borgia
IPC分类号： A61K31/55 , A61K45/06 , C07D487/04 , A61K31/519 , C07C67/00 , C07D207/34 , C07D209/42 , C07D401/04 , C12N9/99
CPC分类号： C07D487/04 , A61K31/519 , A61K31/55 , A61K45/06 , C07C67/00 , C07D207/34 , C07D209/42 , C07D401/04 , C12N9/99
摘要： The present invention relates to tricyclic pyrrolo derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及调节蛋白激酶活性的三环吡咯衍生物，因此可用于治疗由调节蛋白激酶活性引起的疾病。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物，以及使用这些化合物治疗疾病的方法或含有它们的药物组合物的方法。
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公开(公告)号：US20150065520A1
公开(公告)日：2015-03-05
申请号：US14534617
申请日：2014-11-06
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： C07D405/12
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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公开(公告)号：US09085558B2
公开(公告)日：2015-07-21
申请号：US14534629
申请日：2014-11-06
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： A61K31/497 , C07D405/12 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 式（I）的取代的吲唑衍生物及其药学上可接受的盐，如说明书中所定义; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：US20150057292A1
公开(公告)日：2015-02-26
申请号：US14534648
申请日：2014-11-06
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： C07D405/12
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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公开(公告)号：US20150057291A1
公开(公告)日：2015-02-26
申请号：US14534629
申请日：2014-11-06
发明人： Andrea Lombardi Borgia , Maria Menichincheri , Paolo Orsini , Achille Panzeri , Ettore Perrone , Ermes Vanotti , Marcella Nesi , Chiara Marchionni
IPC分类号： C07D405/12
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 式（I）的取代的吲唑衍生物及其药学上可接受的盐，如说明书中所定义; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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