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公开(公告)号：US20240352447A1
公开(公告)日：2024-10-24
申请号：US18750621
申请日：2024-06-21
Applicant: New England Biolabs, Inc.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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公开(公告)号：US20180171328A1
公开(公告)日：2018-06-21
申请号：US15882603
申请日：2018-01-29
Applicant: New England Biolabs, Inc.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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公开(公告)号：US20130115678A1
公开(公告)日：2013-05-09
申请号：US13736561
申请日：2013-01-08
Applicant: NEW ENGLAND BIOLABS, INC.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
IPC: C12N9/22
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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公开(公告)号：US09034625B2
公开(公告)日：2015-05-19
申请号：US13736152
申请日：2013-01-08
Applicant: New England Biolabs, Inc.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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公开(公告)号：US20130115677A1
公开(公告)日：2013-05-09
申请号：US13736406
申请日：2013-01-08
Applicant: NEW ENGLAND BIOLABS, INC.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
IPC: C12N9/22
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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Patent Agency Ranking
公开(公告)号：US09074196B2
公开(公告)日：2015-07-07
申请号：US13736529
申请日：2013-01-08
Applicant: New England Biolabs, Inc.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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公开(公告)号：US08628945B2
公开(公告)日：2014-01-14
申请号：US13736170
申请日：2013-01-08
Applicant: New England Biolabs, Inc.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
IPC: C12N9/22
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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公开(公告)号：US20130115680A1
公开(公告)日：2013-05-09
申请号：US13736170
申请日：2013-01-08
Applicant: NEW ENGLAND BIOLABS, INC.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
IPC: C12N9/22
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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公开(公告)号：US12054707B2
公开(公告)日：2024-08-06
申请号：US17227799
申请日：2021-04-12
Applicant: New England Biolabs, Inc.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
CPC classification number: C12N15/1058 , C12N9/16 , C12N9/22 , C12N15/1034 , C12N15/1086
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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公开(公告)号：US20210230581A1
公开(公告)日：2021-07-29
申请号：US17227799
申请日：2021-04-12
Applicant: New England Biolabs, Inc.
Inventor： Zhenyu Zhu , Aine Quimby , Shuang-Yong Xu , Shengxi Guan , Hua Wei , Penghua Zhang , Dapeng Sun , Siu-hong Chan
Abstract: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction endonucleases with reduced star activity as defined by an overall fidelity index improvement factor.
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