公开(公告)号：US20190010238A1

公开(公告)日：2019-01-10

申请号：US16031418

申请日：2018-07-10

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Allal BOUTAJANGOUT

IPC: C07K16/28 ,  C07K16/10 ,  A61P25/28 ,  A61P25/18

CPC classification number: C07K16/2872 ,  A61K2039/505 ,  A61P25/18 ,  A61P25/28 ,  C07K16/1036 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34

Abstract: The present invention is directed to an anti-prion monoclonal antibody and its use for the treatment of conditions associated with or mediated by proteins or peptides having a toxic oligomeric form. These conditions include, but are not limited to, Alzheimer's disease, frontotemporal dementias, traumatic brain injury, and chronic traumatic encephalopathy.