公开(公告)号：US20160303208A1

公开(公告)日：2016-10-20

申请号：US15076122

申请日：2016-03-21

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Fernando GONI

IPC: A61K39/00 ,  A61K39/39

CPC classification number: A61K39/0007 ,  A61K38/18 ,  A61K39/0005 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55 ,  A61K2039/555 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/575 ,  A61K2039/58 ,  C07K14/4711

Abstract: The invention relates to methods for treating human amyloid disease by administration of modified Aβ peptide immunogens.

Abstract translation: 本发明涉及通过施用经修饰的Aβ肽免疫原来治疗人淀粉样蛋白病的方法。

公开(公告)号：US20190256612A1

公开(公告)日：2019-08-22

申请号：US16319682

申请日：2017-07-22

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas M. WISNIEWSKI ,  Fernando GONI

IPC: C07K16/44 ,  A61P25/28 ,  C07K16/18 ,  C07K7/06

Abstract: The present invention relates to antibodies and binding fragments thereof that bind the β-sheet secondary structure of a pathological monomeric or oligomeric non-fibrillar proteins without binding to the non-toxic, non-pathological forms of these proteins or peptides These antibodies and binding fragments thereof are suitable for the diagnosis, prevention, and treatment of protein conformational disorders including all amyloid diseases.

公开(公告)号：US20180305407A1

公开(公告)日：2018-10-25

申请号：US15830902

申请日：2017-12-04

Applicant: New York University

Inventor： Thomas M. WISNIEWSKI ,  Fernando GONI

IPC: C07K7/08 ,  A61K38/10 ,  A61K39/00 ,  C07K16/18 ,  A61K9/00 ,  A61K39/395

CPC classification number: C07K7/08 ,  A61K9/0019 ,  A61K38/10 ,  A61K39/0007 ,  A61K39/3955 ,  A61K2039/55505 ,  C07K16/18 ,  C07K2317/34 ,  C07K2319/70

Abstract: The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease.

公开(公告)号：US20230130218A1

公开(公告)日：2023-04-27

申请号：US17743854

申请日：2022-05-13

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas M. WISNIEWSKI ,  Fernando GONI

IPC: C07K14/47 ,  G01N33/68 ,  A61K9/00 ,  A61K39/00 ,  C07K16/18

Abstract: The present invention is directed to polymerized products and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease.

公开(公告)号：US20150165005A1

公开(公告)日：2015-06-18

申请号：US14559301

申请日：2014-12-03

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas WISNIEWSKI ,  Fernando GONI

IPC: A61K39/00 ,  A61K39/39 ,  A61K38/18 ,  C07K14/47

CPC classification number: A61K39/0007 ,  A61K38/18 ,  A61K39/0005 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55 ,  A61K2039/555 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/575 ,  A61K2039/58 ,  C07K14/4711

Abstract: The invention relates to methods for treating human amyloid disease by administration of modified Aβ peptide immunogens.

Abstract translation: 本发明涉及通过施用改良的A＆Bgr来治疗人淀粉样蛋白病的方法。 肽免疫原。

公开(公告)号：US20220313802A1

公开(公告)日：2022-10-06

申请号：US17610388

申请日：2020-05-11

Applicant: NEW YORK UNIVERSITY ,  INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA (INTA) ,  UNIVERSIDAD DE LA REPUBLICA

Inventor： Fernando GONI ,  Thomas WISNIEWSKI ,  Lucia YIM ,  Jose Alejandro CHABALGOITY ,  Analia ELISEI

IPC: A61K39/00 ,  A61P25/28 ,  C07K14/47 ,  C07K16/28

Abstract: The present disclosure is directed to a multi-species prion protein or peptide thereof, and vaccine compositions comprising the same that are useful for the vaccination and treatment of mammalian subjects at risk of having or having prion disease. Also disclosed herein are isolated proteins and peptides, polymers, vaccines, animal bait or feed, antibodies, and methods of inhibiting the onset of or treating a prion disease.

公开(公告)号：US20210324110A1

公开(公告)日：2021-10-21

申请号：US17098026

申请日：2020-11-13

Applicant: NEW YORK UNIVERSITY

Inventor： Thomas M. WISNIEWSKI ,  Fernando GONI

IPC: C07K16/44 ,  A61P25/28 ,  C07K7/06 ,  C07K16/18 ,  C07K14/00

Abstract: The present invention relates to antibodies and binding fragments thereof that bind the β-sheet secondary structure of a pathological monomeric or oligomeric non-fibrillar proteins without binding to the non-toxic, non-pathological forms of these proteins or peptides. These antibodies and binding fragments thereof are suitable for the diagnosis, prevention, and treatment of protein conformational disorders including all amyloid diseases.