公开(公告)号：US20200113801A1

公开(公告)日：2020-04-16

申请号：US16498951

申请日：2018-03-19

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  NIBEC CO., LTD.

发明人： Seung Hyun HAN ,  Kee-Yeon KUM ,  Ki Bum AHN ,  Ok-Jin PARK ,  Chong-Pyoung CHUNG ,  Yoon Jeong PARK ,  Jue-Yeon LEE

IPC分类号： A61K8/64 ,  A61K8/19 ,  A61K8/43 ,  A61Q11/00

摘要： The present invention relates to: a composition for inhibiting biofilms, containing, as an active ingredient, a peptide derived from human β-defensin-3; and a method for inhibiting biofilms by using the composition. The peptide according to the present invention inhibits bacterial biofilms even when used alone and exhibits a remarkably increased biofilm inhibitory effect when used in combination with a conventional dental therapeutic agent, and has an effect of preventing a tooth discoloration side effect caused by a conventional dental therapeutic agent.

公开(公告)号：US20210147482A1

公开(公告)日：2021-05-20

申请号：US16625692

申请日：2018-06-19

申请人： NIBEC CO., LTD. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Seung Hyun HAN ,  Ok-Jin PARK ,  Jiseon KIM ,  Ki Bum AHN ,  Yoon Jeong PARK ,  Chong-Pyoung CHUNG ,  Jue-Yeon LEE

IPC分类号： C07K7/08 ,  A61P19/08

摘要： The present invention relates to a peptide for inhibiting bone resorption and, more specifically, to a peptide for inhibiting bone destruction by inhibiting the differentiation and activity of osteoclasts. According to the present invention, a peptide for inhibiting bone resorption can inhibit bone destruction by inhibiting the differentiation and activity of osteoclasts, and thus can be used as a therapeutic agent for various bone diseases caused by an excessive increase in the activity of osteoclasts.