公开(公告)号：US10047047B2

公开(公告)日：2018-08-14

申请号：US15561919

申请日：2016-03-22

Applicant: Nicox S.A.

Inventor： Nicoletta Almirante ,  Laura Storoni ,  Elena Bastia ,  Stefania Brambilla ,  Francesco Impagnatiello

IPC: C07C405/00 ,  A61P27/02 ,  A61P27/06 ,  A61K45/06 ,  A61K31/5575 ,  A61K9/00

Abstract: The present invention relates to 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid.

公开(公告)号：US11980618B2

公开(公告)日：2024-05-14

申请号：US17265134

申请日：2019-07-31

Applicant: NICOX S.A.

Inventor： Nicoletta Almirante ,  Stefania Brambilla ,  Laura Storoni ,  Francesco Impagnatiello ,  Elena Bastia

IPC: A61K31/506 ,  A61K31/197 ,  A61K31/519 ,  A61K45/06 ,  A61P27/06 ,  C07D403/14 ,  C07D487/04

CPC classification number: A61K31/506 ,  A61K31/197 ,  A61K31/519 ,  A61K45/06 ,  A61P27/06 ,  C07D403/14 ,  C07D487/04

Abstract: The invention relates to nitric oxide releasing phosphodiesterase type 5 (PDE5) inhibitors of formula or a stereoisomer or a pharmaceutically acceptable salt thereof:






useful for the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies.

公开(公告)号：US10280138B2

公开(公告)日：2019-05-07

申请号：US15561885

申请日：2016-01-28

Applicant: NICOX S.A.

Inventor： Nicoletta Almirante ,  Laura Storoni ,  Elena Bastia ,  Stefania Brambilla ,  Francesco Impagnatiello

IPC: A61K31/5575 ,  A61P27/06 ,  C07D405/00 ,  C07C405/00

Abstract: The present invention relates to 15-nitrooxyderivatives of fluprostenol, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxy derivatives of fluprostenol.