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公开(公告)号：US10047047B2
公开(公告)日：2018-08-14
申请号：US15561919
申请日：2016-03-22
Applicant: Nicox S.A.
Inventor： Nicoletta Almirante , Laura Storoni , Elena Bastia , Stefania Brambilla , Francesco Impagnatiello
IPC: C07C405/00 , A61P27/02 , A61P27/06 , A61K45/06 , A61K31/5575 , A61K9/00
Abstract: The present invention relates to 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid.
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公开(公告)号：US09266820B2
公开(公告)日：2016-02-23
申请号：US14300049
申请日：2014-06-09
Applicant: NICOX S.A.
Inventor： Nicoletta Almirante , Stefano Biondi , Ennio Ongini , Laura Storoni , Alessia Nicotra
IPC: C07C291/02 , A61K31/21 , C07C229/20 , C07C203/02 , C07C229/08 , C07C229/22 , C07C229/24 , C07C229/26 , C07C229/36 , C07C237/08 , C07C271/22 , C07C279/14 , C07C323/58 , C07D207/16 , C07D209/52 , A61K31/223 , A61K31/225 , A61K31/265 , A61K31/27 , A61K31/40 , A61K31/403 , A61K45/06
CPC classification number: C07C229/20 , A61K31/223 , A61K31/225 , A61K31/265 , A61K31/27 , A61K31/40 , A61K31/403 , A61K45/06 , C07C203/02 , C07C229/08 , C07C229/22 , C07C229/24 , C07C229/26 , C07C229/36 , C07C237/08 , C07C271/22 , C07C279/14 , C07C291/02 , C07C323/58 , C07D207/16 , C07D209/52
Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metabolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.
Abstract translation: 本发明涉及一氧化氮供体化合物及其用于治疗心血管疾病，炎症，疼痛，发热，胃肠道疾病，眼科疾病，肝脏疾病，肾脏疾病，呼吸系统疾病，免疫疾病，骨代谢功能障碍，中枢和周围神经系统疾病 ，性功能障碍，感染性疾病，用于抑制血小板聚集和血小板粘附，用于治疗由异常细胞增殖，血管疾病引起的病理状况。 本发明还涉及包含至少一种本发明的一氧化一氮释放化合物和包含至少一种根据本发明的一氧化氮释放化合物和至少一种治疗剂的组合物的组合物。
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Patent Agency Ranking
公开(公告)号：US11980618B2
公开(公告)日：2024-05-14
申请号：US17265134
申请日：2019-07-31
Applicant: NICOX S.A.
Inventor： Nicoletta Almirante , Stefania Brambilla , Laura Storoni , Francesco Impagnatiello , Elena Bastia
IPC: A61K31/506 , A61K31/197 , A61K31/519 , A61K45/06 , A61P27/06 , C07D403/14 , C07D487/04
CPC classification number: A61K31/506 , A61K31/197 , A61K31/519 , A61K45/06 , A61P27/06 , C07D403/14 , C07D487/04
Abstract: The invention relates to nitric oxide releasing phosphodiesterase type 5 (PDE5) inhibitors of formula or a stereoisomer or a pharmaceutically acceptable salt thereof:
useful for the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies.-
公开(公告)号：US10280138B2
公开(公告)日：2019-05-07
申请号：US15561885
申请日：2016-01-28
Applicant: NICOX S.A.
Inventor： Nicoletta Almirante , Laura Storoni , Elena Bastia , Stefania Brambilla , Francesco Impagnatiello
IPC: A61K31/5575 , A61P27/06 , C07D405/00 , C07C405/00
Abstract: The present invention relates to 15-nitrooxyderivatives of fluprostenol, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxy derivatives of fluprostenol.
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公开(公告)号：US09079821B2
公开(公告)日：2015-07-14
申请号：US14161520
申请日：2014-01-22
Applicant: NICOX S.A.
Inventor： Gael Ronsin , Laura Storoni , Francesca Benedini
IPC: C07C203/04 , C07C323/22 , C07D307/20 , A61K45/06 , A61K31/341 , A61K31/21
CPC classification number: C07C203/04 , A61K31/21 , A61K31/341 , A61K45/06 , C07C323/22 , C07C2601/16 , C07D307/20 , A61K2300/00
Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
Abstract translation: 本发明涉及具有醌基结构的一氧化氮供体化合物，其制备方法及其用于治疗其缺乏NO在其发病机理中起重要作用的病理状况。
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公开(公告)号：US09061962B2
公开(公告)日：2015-06-23
申请号：US14126363
申请日：2012-10-23
Applicant: NICOX S.A.
Inventor： Gael Ronsin , Laura Storoni , Francesca Benedini
IPC: C07C203/04 , C07C323/53 , C07H11/02 , A61K31/122 , A61K31/7024 , A61K45/06 , C07C323/22 , C07D307/20
CPC classification number: C07C203/04 , A61K31/122 , A61K31/7024 , A61K45/06 , C07C323/22 , C07C323/53 , C07C2601/16 , C07C2602/10 , C07D307/20 , C07H11/02
Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
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公开(公告)号：US20140342998A1
公开(公告)日：2014-11-20
申请号：US14126363
申请日：2012-10-23
Applicant: NICOX S.A.
Inventor： Gael Ronsin , Laura Storoni , Francesca Benedini
IPC: C07C203/04 , A61K31/7024 , C07C323/53 , C07H11/02 , A61K31/122 , A61K45/06
CPC classification number: C07C203/04 , A61K31/122 , A61K31/7024 , A61K45/06 , C07C323/22 , C07C323/53 , C07C2601/16 , C07C2602/10 , C07D307/20 , C07H11/02
Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
Abstract translation: 本发明涉及具有醌基结构的一氧化氮供体化合物，其制备方法及其用于治疗其缺乏NO在其发病机理中起重要作用的病理状况。
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