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公开(公告)号：US10189815B2
公开(公告)日：2019-01-29
申请号：US15321972
申请日：2015-06-25
发明人： Akihiro Izawa , Kei Akama , Yuki Okumura , Yurie Fukui , Nobuya Kobashi , Tsutomu Abe , Yoshihiro Doi , Miho Ikenaga , Hideo Saji , Hiroyuki Kimura , Mitsuhide Naruse
IPC分类号： C07D401/14 , A61K51/00 , A61K31/4439 , A61K51/04
摘要： Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined.
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公开(公告)号：US10358434B2
公开(公告)日：2019-07-23
申请号：US16211434
申请日：2018-12-06
发明人： Akihiro Izawa , Kei Akama , Yuki Okumura , Yurie Fukui , Nobuya Kobashi , Tsutomu Abe , Yoshihiro Doi , Miho Ikenaga , Hideo Saji , Hiroyuki Kimura , Mitsuhide Naruse
IPC分类号： C07D401/14 , A61K51/04 , A61K31/4439 , A61K51/00
摘要： Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined. Methods for producing various radioactive compounds are also provided.
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公开(公告)号：US20230094773A1
公开(公告)日：2023-03-30
申请号：US17825430
申请日：2022-05-26
发明人： Norihito Nakata , Nobuya Kobashi , Yoshinari Shoyama , Mitsuhiro Matono , Yasushi Ochiai , Takayuki Murakami
摘要： The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the radionuclide is a metal nuclide that emits α particle or positron, and the antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.
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公开(公告)号：US11369701B2
公开(公告)日：2022-06-28
申请号：US17367077
申请日：2021-07-02
发明人： Norihito Nakata , Nobuya Kobashi , Yoshinari Shoyama , Mitsuhiro Matono , Yasushi Ochiai , Takayuki Murakami
摘要： The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the radionuclide is a metal nuclide that emits α particle or positron, and the antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.
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公开(公告)号：US20210338852A1
公开(公告)日：2021-11-04
申请号：US17367077
申请日：2021-07-02
发明人： Norihito Nakata , Nobuya Kobashi , Yoshinari Shoyama , Mitsuhiro Matono , Yasushi Ochiai , Takayuki Murakami
摘要： The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the radionuclide is a metal nuclide that emits α particle or positron, and the antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.
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