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公开(公告)号：US20230094773A1
公开(公告)日：2023-03-30
申请号：US17825430
申请日：2022-05-26
发明人： Norihito Nakata , Nobuya Kobashi , Yoshinari Shoyama , Mitsuhiro Matono , Yasushi Ochiai , Takayuki Murakami
摘要： The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the radionuclide is a metal nuclide that emits α particle or positron, and the antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.
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公开(公告)号：US11369701B2
公开(公告)日：2022-06-28
申请号：US17367077
申请日：2021-07-02
发明人： Norihito Nakata , Nobuya Kobashi , Yoshinari Shoyama , Mitsuhiro Matono , Yasushi Ochiai , Takayuki Murakami
摘要： The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the radionuclide is a metal nuclide that emits α particle or positron, and the antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.
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公开(公告)号：US09107964B2
公开(公告)日：2015-08-18
申请号：US14345493
申请日：2012-09-18
发明人： Norihito Nakata , Yuki Okumura , Masato Kiriu , Eriko Nagata , Hiroki Matsumoto , Yuji Kuge , Songji Zhao , Ken-Ichi Nishijima
IPC分类号： C07D233/91 , C07D405/06 , A61K51/04 , C07B59/00
CPC分类号： A61K51/0453 , A61K2123/00 , C07B59/002 , C07D233/91 , C07D405/06
摘要： The present invention is a compound represented by the following formula (1) or a salt thereof. In the formula (1), R1 denotes a hydrogen atom, a methyl group, or a hydroxymethyl group, and n is an integer of 1 or 2.
摘要翻译： 本发明是由下式（1）表示的化合物或其盐。 在式（1）中，R 1表示氢原子，甲基或羟甲基，n为1或2的整数。
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公开(公告)号：US20140364620A1
公开(公告)日：2014-12-11
申请号：US14345493
申请日：2012-09-18
发明人： Norihito Nakata , Yuki Okumura , Masato Kiriu , Eriko Nagata , Hiroki Matsumoto , Yuji Kuge , Songji Zhao , Ken-Ichi Nishijima
IPC分类号： A61K51/04 , C07B59/00 , C07D233/91
CPC分类号： A61K51/0453 , A61K2123/00 , C07B59/002 , C07D233/91 , C07D405/06
摘要： The present invention is a compound represented by the following formula (1) or a salt thereof. In the formula (1), R1 denotes a hydrogen atom, a methyl group, or a hydroxymethyl group, and n is an integer of 1 or 2.
摘要翻译： 本发明是由下式（1）表示的化合物或其盐。 在式（1）中，R 1表示氢原子，甲基或羟甲基，n为1或2的整数。
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公开(公告)号：US20210338852A1
公开(公告)日：2021-11-04
申请号：US17367077
申请日：2021-07-02
发明人： Norihito Nakata , Nobuya Kobashi , Yoshinari Shoyama , Mitsuhiro Matono , Yasushi Ochiai , Takayuki Murakami
摘要： The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the radionuclide is a metal nuclide that emits α particle or positron, and the antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.
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