公开(公告)号：US20230117773A1

公开(公告)日：2023-04-20

申请号：US17937866

申请日：2022-10-04

Applicant: NOBLIS, INC.

Inventor： Shane MITCHELL ,  Sterling Thomas ,  Masooda Omari ,  Tyler W. Barrus ,  Mychal Ivancich

IPC: C12Q1/6851 ,  C12Q1/6806 ,  C12Q1/6811 ,  C12Q1/6825 ,  C12Q1/6855 ,  G16B30/00

Abstract: Portable biosurveillance kits for sequencing and sample identification are provided, and techniques for configuring said kits are provided. A system for configuring a kit may receive data representing a first and second set of nucleic acid sequences, and may generate and store first and second indexes representing the respective sets. The system may then use the indexes to identify conserved-signature sequences that satisfy abundance criteria with respect to the first set and sparsity criteria with respect to the second set. The identified conserved-signature sequences may be stored on (or represented in storage on) a portable sequencing and sample-identification kit, which may compare the conserved-signature sequence to a sample sequence in order to identify the sample sequence.

公开(公告)号：US10191929B2

公开(公告)日：2019-01-29

申请号：US13904738

申请日：2013-05-29

Applicant: Noblis, Inc.

Inventor： Sterling Thomas ,  Nathan Dellinger

IPC: G06F17/30 ,  G06F19/22

Abstract: In one embodiment, a system comprising a processor and a memory storing instructions executable by the processor creates an index for a nucleic acid sequence. The index comprises a plurality of elements. Each element corresponds to a permutation of a nucleic acid sequence. Data representing a nucleic acid sequence is received. A subsequence of the nucleic acid sequence is identified in the data at a first position of the nucleic acid sequence. A hash of the subsequence is computed to determine a corresponding element of the index. Position data reflecting the first position is stored in the corresponding element of the index.

公开(公告)号：US12195729B2

公开(公告)日：2025-01-14

申请号：US17231280

申请日：2021-04-15

Applicant: NOBLIS, INC.

Inventor： Shane Mitchell ,  Masooda Omari ,  Sterling Thomas ,  Leo Thompson

IPC: C12N15/10 ,  B01L7/00 ,  C12Q1/6806 ,  C12Q1/6869

Abstract: A portable kit for nucleic acid sequencing is disclosed, the kit including a DNA extraction system configured to perform a DNA extraction protocol, a DNA sequencing preparation system configured to perform a DNA sequencing preparation protocol, a sequencer system, and a portable enclosure configured to house the DNA extraction system, the sequencer preparation system, and the sequencer system.

公开(公告)号：US10560552B2

公开(公告)日：2020-02-11

申请号：US14718950

申请日：2015-05-21

Applicant: NOBLIS, INC.

Inventor： Sterling Thomas ,  Nate Dellinger ,  Mychal Ivancich

IPC: H04L29/06 ,  H03M7/30 ,  G16B30/00

Abstract: Systems and methods for performing genomic information compression, transmission, and decompression are provided. A system for compression, transmission, and decompression of genomic information includes a first computer associated with a first index and a second computer associated with a second index, each index containing reference permutations of nucleic acid sequence portions, each permutation associated with a reference number. The first computer uses input genomic information and the first index to produce a compressed representation of the genomic information, and transmits the compressed representation to the second computer. The second computer uses the compressed representation and the second index to assemble a data representation of the genomic information. The compressed representation comprises references to permutations, indications of locations of each permutation in the input information, indications of variations to permutations, and/or indications of sequence length.

公开(公告)号：US12141116B2

公开(公告)日：2024-11-12

申请号：US17723053

申请日：2022-04-18

Applicant: NOBLIS, INC.

Inventor： Sterling Thomas ,  Nathan Dellinger

IPC: G06F16/22 ,  G16B30/00 ,  G16B30/10

Abstract: In some embodiments, techniques for identifying one or more species in an undifferentiated environmental sample comprising a plurality of nucleic acid sequences are provided. One or more indices that represent a plurality of reference nucleic acid sequences may be provided, and data may be received comprising digital representations of respective nucleic acid sequences. The respective nucleic acid sequences may be aligned, if possible, using the indices. A respective alignment ration may be calculated for each one of the reference nucleic acid sequences, based on the number of nucleic acid sequences aligned to the respective reference nucleic acid sequence and the total number of nucleic acid sequences in the received data.

公开(公告)号：US11308056B2

公开(公告)日：2022-04-19

申请号：US16257552

申请日：2019-01-25

Applicant: NOBLIS, INC.

Inventor： Sterling Thomas ,  Nathan Dellinger

IPC: G06F16/00 ,  G06F16/22 ,  G16B30/00 ,  G16B30/10

Abstract: In some embodiments, techniques for identifying one or more species in an undifferentiated environmental sample comprising a plurality of nucleic acid sequences are provided. One or more indices that represent a plurality of reference nucleic acid sequences may be provided, and data may be received comprising digital representations of respective nucleic acid sequences. The respective nucleic acid sequences may be aligned, if possible, using the indices. A respective alignment ration may be calculated for each one of the reference nucleic acid sequences, based on the number of nucleic acid sequences aligned to the respective reference nucleic acid sequence and the total number of nucleic acid sequences in the received data.