公开(公告)号：US20240200025A1

公开(公告)日：2024-06-20

申请号：US18574611

申请日：2022-06-27

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Ryutaro IMAMURA ,  Tomoyuki OHTAKE ,  Atsushi MARUYAMA ,  Naohiko SHIMADA

IPC: C12N5/00

CPC classification number: C12N5/0081 ,  C12N2509/00

Abstract: The present invention provides a cell detachment agent for detaching a cell to be separated from a separation carrier bound to the cell to be separated, wherein the above-mentioned cell detachment agent contains a bindable ureido group-containing polymer having a side chain structure represented by the following formula (1) and having a separation carrier-binding site capable of binding to the above-mentioned separation carrier at a side chain or terminal thereof, and the above-mentioned bindable ureido group-containing polymer has an upper critical solution temperature (UCST) of 4 to 40° C.:


—NH—(C═O)—NH2  (1)

公开(公告)号：US20210017309A1

公开(公告)日：2021-01-21

申请号：US16955375

申请日：2018-12-26

Applicant: NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITY ,  NOF CORPORATION

Inventor： Hideharu MORI ,  Ryutaro IMAMURA

IPC: C08F20/58 ,  C08F8/02 ,  C07C321/18

Abstract: Provided is a zwitterionic polymer that has a zwitterion that includes an effect of improving the stability of proteins. This zwitterionic polymer is a polymeric protein stabilizer that exhibits a protein stabilizing effect even at a small addition amount of addition, and at the same time has an antioxidant capability. Also provided is a method for producing this zwitterionic polymer. This problem is solved by a zwitterionic polymer containing a repeating unit represented by formula (1) and having a number-average molecular weight of 1,000 to 1,000,000. On formula (1), R1 and R2 are each independently selected from a hydrogen atom; linear, branched or cyclic alkyl groups having 1 to 6 carbons; aromatic groups having 6 to 20 carbons; or alkylene groups having 1 to 6 carbons and formed by linking R1 to R2. R3 represents a hydrogen atom or a methyl group).

公开(公告)号：US20180186931A1

公开(公告)日：2018-07-05

申请号：US15740252

申请日：2016-06-29

Applicant: TOHOKU TECHNO ARCH CO., LTD. ,  NOF CORPORATION

Inventor： Kazushi KINBARA ,  Takahiro MURAOKA ,  Marcin Adam WAWRO ,  Tomoyuki OHTAKE ,  Eui-chul KANG ,  Tomoki URUGA ,  Ryutaro IMAMURA

IPC: C08G65/46 ,  C08G65/48 ,  B01D11/04 ,  B01D15/36

CPC classification number: C08G65/46 ,  B01D11/0492 ,  B01D15/362 ,  B01D15/363 ,  B01D15/366 ,  C08G65/333 ,  C08G65/334 ,  C08G65/48 ,  C08G2650/50

Abstract: A hetero type monodispersed polyethylene glycol containing a compound represented by the following formula (1): NH2—(CH2CH2O)a—CH2CH2COOH  (1) (in the formula (1), a represents an integer from 6 to 40); wherein any of (A) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using reverse phase chromatography, (B) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using cation exchange chromatography, and (C) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol containing a compound represented by the formula (1) shown above is derivatized and separated using anion exchange chromatography satisfy specific relational expressions, respectively.