公开(公告)号：US11737978B2

公开(公告)日：2023-08-29

申请号：US16942267

申请日：2020-07-29

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Sijia Yi ,  David Engman ,  Xiaomo Li

IPC: A61K9/127 ,  A61K31/4168 ,  A61P33/02 ,  A61K47/34 ,  A61K9/107

CPC classification number: A61K9/1273 ,  A61K9/1075 ,  A61K31/4168 ,  A61K47/34 ,  A61P33/02

Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.

公开(公告)号：US10821078B2

公开(公告)日：2020-11-03

申请号：US15637333

申请日：2017-06-29

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Sijia Yi ,  Sean D. Allen

IPC: A61K9/127 ,  A61K47/34 ,  C08G65/334 ,  A61K49/00 ,  C08G75/14

Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.

公开(公告)号：US20200316186A1

公开(公告)日：2020-10-08

申请号：US16839861

申请日：2020-04-03

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Chyung-Ru Wang ,  Shaobin Shang ,  Dina Kats

IPC: A61K39/04 ,  A61K9/51

Abstract: Provided herein are subunit vaccine compositions comprising a nanocarrier and a lipid antigen, a peptide antigen or combinations thereof that elicit bother a CD1-restricted and an MHC-restricted T cell response in a subject. Methods for making and using the subunit vaccine compositions are also provided.

公开(公告)号：US20230330022A1

公开(公告)日：2023-10-19

申请号：US18346721

申请日：2023-07-03

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Sijia Yi ,  David Engman ,  Xiaomo Li

IPC: A61K9/127 ,  A61K47/34 ,  A61K31/4168 ,  A61P33/02 ,  A61K9/107

CPC classification number: A61K9/1273 ,  A61K9/1075 ,  A61K31/4168 ,  A61K47/34 ,  A61P33/02

Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.

公开(公告)号：US20210106697A1

公开(公告)日：2021-04-15

申请号：US17071653

申请日：2020-10-15

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Evan A. Scott ,  Guillermo A. Ameer ,  Jacqueline A. Burke ,  Helena Freire Haddad

IPC: A61K49/00 ,  A01K67/027

Abstract: The present invention provides methods of making an in vivo animal model for detecting anti-poly(ethylene glycol) (PEG) antibodies. The methods of the disclosure comprises administering subcutaneously to an animal model a composition comprising antibodies against poly(ethylene glycol) chains with a molecular weight of at least 550 Da to maintain an anti-PEG antibody level within the animal model. The in vivo animal model can be used for testing and screening drugs and other compositions for adverse reactions, bioavailability, and immunogenicity prior to administration to a human subject.

公开(公告)号：US20210059938A1

公开(公告)日：2021-03-04

申请号：US17085223

申请日：2020-10-30

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Sijia Yi ,  Sean D. Allen

IPC: A61K9/127 ,  A61K47/34 ,  C08G65/334 ,  A61K49/00 ,  C08G75/14

Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.

公开(公告)号：US12194084B2

公开(公告)日：2025-01-14

申请号：US17645288

申请日：2021-12-20

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Chyung-Ru Wang ,  Shaobin Shang ,  Dina Kats

IPC: A61K39/04 ,  A61K9/51 ,  A61K39/00

Abstract: Provided herein are subunit vaccine compositions comprising a nanocarrier and a lipid antigen, a peptide antigen or combinations thereof that elicit bother a CD1-restricted and an MHC-restricted T cell response in a subject. Methods for making and using the subunit vaccine compositions are also provided.

公开(公告)号：US12162997B2

公开(公告)日：2024-12-10

申请号：US17448151

申请日：2021-09-20

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Sean D. Allen

IPC: C08J3/14 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K31/352 ,  A61K31/365 ,  A61K31/436 ,  A61K38/46 ,  A61K47/34 ,  A61K47/36 ,  A61K49/00 ,  B01F23/41 ,  B01F23/45 ,  B01F25/20 ,  B01F25/23 ,  B01F33/30 ,  C12N15/113

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

公开(公告)号：US11124612B2

公开(公告)日：2021-09-21

申请号：US16845831

申请日：2020-04-10

Applicant: Northwestern University

Inventor： Evan A. Scott ,  Sean D. Allen

IPC: A61K31/352 ,  A61K31/436 ,  A61K31/365 ,  A61K47/34 ,  A61K47/36 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K49/00 ,  C08J3/14 ,  B01F13/00 ,  B01F5/02 ,  B01F3/08 ,  A61K38/46 ,  C12N15/113

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

公开(公告)号：US11890353B2

公开(公告)日：2024-02-06

申请号：US17071653

申请日：2020-10-15

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Evan A. Scott ,  Guillermo A. Ameer ,  Jacqueline A. Burke ,  Helena Freire Haddad

IPC: A61K49/00 ,  A01K67/027

CPC classification number: A61K49/0008 ,  A01K67/027 ,  A01K2207/10 ,  A01K2227/105 ,  A01K2267/03

Abstract: The present invention provides methods of making an in vivo animal model for detecting anti-poly(ethylene glycol) (PEG) antibodies. The methods of the disclosure comprises administering subcutaneously to an animal model a composition comprising antibodies against poly(ethylene glycol) chains with a molecular weight of at least 550 Da to maintain an anti-PEG antibody level within the animal model. The in vivo animal model can be used for testing and screening drugs and other compositions for adverse reactions, bioavailability, and immunogenicity prior to administration to a human subject.