公开(公告)号：US20180280476A1

公开(公告)日：2018-10-04

申请号：US16003394

申请日：2018-06-08

申请人： NOVARTIS AG

发明人： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett ,  Chris Xiangyang Lu ,  Jing Wu

IPC分类号： A61K38/18 ,  A61K45/06 ,  G01N33/50 ,  G01N33/74 ,  A61K39/395 ,  A61K38/16 ,  A61K31/7088

摘要： The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.