公开(公告)号：US20190153084A1

公开(公告)日：2019-05-23

申请号：US16027954

申请日：2018-07-05

申请人： NOVARTIS AG

发明人： Zijun Chen ,  Sujun Deng ,  Yun He ,  Dagang Huang ,  Markus Kugler ,  Qian Li ,  Chris Xiangyang Lu ,  Xiao Luo ,  Yongqiang Shan ,  Kathrin Ulrike Tissot-Daguette ,  Jing Wu

IPC分类号： C07K16/22 ,  C12N15/09 ,  A61K45/06 ,  C12N15/63 ,  A61K38/18 ,  A61K31/7072 ,  A61K31/675 ,  A61K31/575 ,  A61K31/522 ,  A61K31/513 ,  A61K31/497 ,  A61K31/4725 ,  A61K31/4439 ,  A61K31/355 ,  A61K31/155 ,  A61K39/395

摘要： The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.

公开(公告)号：US10047155B2

公开(公告)日：2018-08-14

申请号：US15165150

申请日：2016-05-26

申请人： NOVARTIS AG

发明人： Zijun Chen ,  Sujun Deng ,  Yun He ,  Dagang Huang ,  Markus Kugler ,  Qian Li ,  Chris Xiangyang Lu ,  Xiao Luo ,  Yongqiang Shan ,  Kathrin Ulrike Tissot-Daguette ,  Jing Wu

IPC分类号： C07K16/22 ,  A61K39/395 ,  A61K38/18 ,  C12N15/13 ,  C12N15/63 ,  C12N15/09 ,  A61K45/06 ,  A61K31/155 ,  A61K31/355 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/513 ,  A61K31/522 ,  A61K31/575 ,  A61K31/675 ,  A61K31/7072 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K31/155 ,  A61K31/355 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/513 ,  A61K31/522 ,  A61K31/575 ,  A61K31/675 ,  A61K31/7072 ,  A61K38/1875 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C12N15/09 ,  C12N15/63 ,  A61K2300/00

摘要： The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.

公开(公告)号：US20180280476A1

公开(公告)日：2018-10-04

申请号：US16003394

申请日：2018-06-08

申请人： NOVARTIS AG

发明人： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett ,  Chris Xiangyang Lu ,  Jing Wu

IPC分类号： A61K38/18 ,  A61K45/06 ,  G01N33/50 ,  G01N33/74 ,  A61K39/395 ,  A61K38/16 ,  A61K31/7088

摘要： The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.