公开(公告)号：US09926314B2

公开(公告)日：2018-03-27

申请号：US15220149

申请日：2016-07-26

Applicant: NOVARTIS AG

Inventor： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC: C07D471/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

公开(公告)号：US20240352030A1

公开(公告)日：2024-10-24

申请号：US18657123

申请日：2024-05-07

Applicant: NOVARTIS AG

Inventor： Cyrille Kounde ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Gang Quan Wang ,  Hui Quan Yeo ,  Bryan KS Yeung ,  Fumiaki Yokokawa ,  Bin Zou

IPC: C07D495/04 ,  A61K45/06 ,  A61K47/06 ,  A61P31/12

CPC classification number: C07D495/04 ,  A61K45/06 ,  A61K47/06 ,  A61P31/12

Abstract: A compound of Formula (1) is provided that has been shown to be useful for treating a disease caused by a viral infection:




wherein R1, R2, R3, A, L, m, n, p and q are as defined herein.

公开(公告)号：US20220073535A1

公开(公告)日：2022-03-10

申请号：US17253755

申请日：2019-06-18

Applicant: NOVARTIS AG

Inventor： Cyrille Kounde ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Gang Wang ,  Hui Quan Yeo ,  Bryan KS Yeung ,  Fumiaki Yokokawa ,  Bin Zou

IPC: C07D495/04 ,  A61P31/12 ,  A61K45/06 ,  A61K47/06

Abstract: A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection: (I) wherein R1, R2, R3, A, L, m, n, p and q are as defined herein.

公开(公告)号：US12012417B2

公开(公告)日：2024-06-18

申请号：US17253755

申请日：2019-06-18

Applicant: NOVARTIS AG

Inventor： Cyrille Kounde ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Gang Wang ,  Hui Quan Yeo ,  Bryan K S Yeung ,  Fumiaki Yokokawa ,  Bin Zou

IPC: C07D495/04 ,  A61K31/4365 ,  A61K45/06 ,  A61K47/06 ,  A61P31/12

CPC classification number: C07D495/04 ,  A61K45/06 ,  A61K47/06 ,  A61P31/12

Abstract: A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection: (I) wherein R1, R2, R3, A, L, m, n, p and q are as defined herein.

公开(公告)号：US09556169B2

公开(公告)日：2017-01-31

申请号：US14443609

申请日：2013-11-18

Applicant: NOVARTIS AG

Inventor： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Jocelyn Liying Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。