公开(公告)号：US20220324863A1

公开(公告)日：2022-10-13

申请号：US17744432

申请日：2022-05-13

Applicant: NOVARTIS AG

Inventor： Jan Jiricek ,  Isabelle K. Lerario ,  Fang Liang ,  Xiaodong Liu ,  Valentina Molteni ,  Advait Suresh Nagle ,  Shuyi Pearly NG ,  Maxim Ratnikov ,  Jeffrey M. Smith ,  Yongping Xie

IPC: C07D471/04 ,  A61P33/02 ,  C07D519/00

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US10596175B2

公开(公告)日：2020-03-24

申请号：US16116418

申请日：2018-08-29

Applicant: NOVARTIS AG

Inventor： Agnes Biggart ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Vince Yeh

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  C07F5/02 ,  C07F7/08 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06

Abstract: The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US09926314B2

公开(公告)日：2018-03-27

申请号：US15220149

申请日：2016-07-26

Applicant: NOVARTIS AG

Inventor： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC: C07D471/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

公开(公告)号：US20170333437A1

公开(公告)日：2017-11-23

申请号：US15600183

申请日：2017-05-19

Applicant: NOVARTIS AG

Inventor： Agnes BIGGART ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Valentina MOLTENI ,  Advait Suresh Nagle ,  Frantisek SUPEK ,  Vince YEH

IPC: A61K31/519 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06

CPC classification number: A61K31/519 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F5/027 ,  C07F7/0814

Abstract: The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US11384078B2

公开(公告)日：2022-07-12

申请号：US16615749

申请日：2018-05-29

Applicant: NOVARTIS AG

Inventor： Jan Jiricek ,  Isabelle K. Lerario ,  Fang Liang ,  Xiaodong Liu ,  Valentina Molteni ,  Advait Suresh Nagle ,  Shuyi Pearly Ng ,  Maxim Ratnikov ,  Jeffrey M. Smith ,  Yongping Xie

IPC: A61K31/7048 ,  A61K31/541 ,  A61K31/197 ,  A61K31/155 ,  A61K31/555 ,  A61K31/417 ,  C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  A61P33/02

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US11123348B2

公开(公告)日：2021-09-21

申请号：US16780628

申请日：2020-02-03

Applicant: NOVARTIS AG

Inventor： Agnes Biggart ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Vince Yeh

IPC: A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  C07F5/02 ,  C07F7/08 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06

Abstract: The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US10085989B2

公开(公告)日：2018-10-02

申请号：US15600183

申请日：2017-05-19

Applicant: NOVARTIS AG

Inventor： Agnes Biggart ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Vince Yeh

IPC: A61K31/519 ,  A61K45/06 ,  A61K31/695 ,  A61K31/5377

Abstract: The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

公开(公告)号：US09556169B2

公开(公告)日：2017-01-31

申请号：US14443609

申请日：2013-11-18

Applicant: NOVARTIS AG

Inventor： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Jocelyn Liying Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。