公开(公告)号：US20230256017A1

公开(公告)日：2023-08-17

申请号：US17801669

申请日：2021-02-26

Applicant: Jennifer BROGDON ,  Glenn DRANOFF ,  Michael R. GREENE ,  Anniesha HACK ,  Olja KODRASI ,  Elizabeth Dorothy PRATICO ,  Andrew PRICE ,  Andrew Marc STEIN ,  Amy RAYO ,  Jennifer YANG ,  Brian Walter GRANDA ,  Novartis AG

Inventor： Jennifer BROGDON ,  Glenn DRANOFF ,  Michael R. GREENE ,  Anniesha HACK ,  Olja KODRASI ,  Elizabeth Dorothy PRATICO ,  Andrew PRICE ,  Andrew Marc STEIN ,  Amy RAYO ,  Jennifer YANG ,  Brian Walter GRANDA ,  Attilio BONDANZA ,  Boris ENGELS ,  Hyungwook LIM ,  Akash SOHONI ,  Louise TREANOR ,  Xu ZHU ,  Carla GUIMARAES ,  Shyamali JAYASHANKAR ,  Sandeep Tharian KOSHY ,  Regis CEBE ,  Michael BARDROFF ,  Sandra MILLER

IPC: A61K35/17 ,  A61P35/00

CPC classification number: A61K35/17 ,  A61P35/00

Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.

公开(公告)号：US20170233443A1

公开(公告)日：2017-08-17

申请号：US15497135

申请日：2017-04-25

Applicant: NOVARTIS AG

Inventor： Alexandra Marshall BRUCE ,  Philipp GROSCHE ,  Carla GUIMARAES ,  Aaron KANTER ,  Changgang LOU ,  Aimee Richardson USERA ,  Kayo YASOSHIMA ,  Jun YUAN ,  Frederic Zecri ,  Hongjuan ZHAO

IPC: C07K14/47 ,  A61K45/06 ,  A61K38/17

CPC classification number: C07K14/47 ,  A61K38/12 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/542 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6811 ,  C07K7/64 ,  C07K14/765 ,  C07K16/461 ,  C07K2319/30 ,  C07K2319/31

Abstract: The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13  I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.