公开(公告)号：US11530413B2

公开(公告)日：2022-12-20

申请号：US16632777

申请日：2018-07-20

Applicant: NOVARTIS AG

Inventor： Eric Billy ,  Antoine De Weck ,  Javad Golji ,  Gregory Hoffman ,  Francesco Hofmann ,  Audrey Kauffmann ,  Konstantinos John Mavrakis ,  Earl Robert McDonald, III ,  William Sellers ,  Tobias Schmelzle ,  Frank Peter Stegmeier ,  Michael Ray Schlabach, Jr.

IPC: C12N15/115 ,  A61K45/06 ,  C12N9/22 ,  C12N15/113 ,  G01N33/574 ,  A61K47/18

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

公开(公告)号：US08957041B2

公开(公告)日：2015-02-17

申请号：US13651808

申请日：2012-10-15

Applicant: Novartis AG

Inventor： Francois Jean-Charles Natt ,  Eric Billy ,  Juerg Hunziker ,  Christian Rene Schnell

IPC: C12N15/11 ,  C07H21/04 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/332 ,  C12N2310/346 ,  C12N2310/3529 ,  C12N2310/50 ,  C12N2310/3521 ,  C12N2310/3533 ,  C12N2310/3525

Abstract: Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.

Abstract translation: 用于口服给药的短干扰核糖核酸（siRNA），所述siRNA包含在至少15个核苷酸上彼此互补的两个单独的RNA链，其中每条链是49个核苷酸或更少，并且其中至少一个链含至少 一种化学改性。