公开(公告)号：US11530413B2

公开(公告)日：2022-12-20

申请号：US16632777

申请日：2018-07-20

Applicant: NOVARTIS AG

Inventor： Eric Billy ,  Antoine De Weck ,  Javad Golji ,  Gregory Hoffman ,  Francesco Hofmann ,  Audrey Kauffmann ,  Konstantinos John Mavrakis ,  Earl Robert McDonald, III ,  William Sellers ,  Tobias Schmelzle ,  Frank Peter Stegmeier ,  Michael Ray Schlabach, Jr.

IPC: C12N15/115 ,  A61K45/06 ,  C12N9/22 ,  C12N15/113 ,  G01N33/574 ,  A61K47/18

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.