公开(公告)号：US20220324863A1

公开(公告)日：2022-10-13

申请号：US17744432

申请日：2022-05-13

Applicant: NOVARTIS AG

Inventor： Jan Jiricek ,  Isabelle K. Lerario ,  Fang Liang ,  Xiaodong Liu ,  Valentina Molteni ,  Advait Suresh Nagle ,  Shuyi Pearly NG ,  Maxim Ratnikov ,  Jeffrey M. Smith ,  Yongping Xie

IPC: C07D471/04 ,  A61P33/02 ,  C07D519/00

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US11384078B2

公开(公告)日：2022-07-12

申请号：US16615749

申请日：2018-05-29

Applicant: NOVARTIS AG

Inventor： Jan Jiricek ,  Isabelle K. Lerario ,  Fang Liang ,  Xiaodong Liu ,  Valentina Molteni ,  Advait Suresh Nagle ,  Shuyi Pearly Ng ,  Maxim Ratnikov ,  Jeffrey M. Smith ,  Yongping Xie

IPC: A61K31/7048 ,  A61K31/541 ,  A61K31/197 ,  A61K31/155 ,  A61K31/555 ,  A61K31/417 ,  C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  A61P33/02

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.