公开(公告)号：US10351576B2

公开(公告)日：2019-07-16

申请号：US15569498

申请日：2016-04-29

Applicant: NOVARTIS AG

Inventor： Donatella Chianelli ,  Xiaodong Liu ,  Valentina Molteni ,  John Nelson ,  Jason Roland ,  Paul Vincent Rucker ,  David Charles Tully

IPC: C07D491/052 ,  C07D493/04 ,  A61K31/4162 ,  A61K31/427 ,  A61K31/5377 ,  A61K31/635

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

公开(公告)号：US11384078B2

公开(公告)日：2022-07-12

申请号：US16615749

申请日：2018-05-29

Applicant: NOVARTIS AG

Inventor： Jan Jiricek ,  Isabelle K. Lerario ,  Fang Liang ,  Xiaodong Liu ,  Valentina Molteni ,  Advait Suresh Nagle ,  Shuyi Pearly Ng ,  Maxim Ratnikov ,  Jeffrey M. Smith ,  Yongping Xie

IPC: A61K31/7048 ,  A61K31/541 ,  A61K31/197 ,  A61K31/155 ,  A61K31/555 ,  A61K31/417 ,  C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  A61P33/02

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US10683271B2

公开(公告)日：2020-06-16

申请号：US16056881

申请日：2018-08-07

Applicant: NOVARTIS AG

Inventor： Donatella Chianelli ,  Xiaodong Liu ,  Valentina Molteni ,  John Nelson ,  Jason Thomas Roland ,  Paul Vincent Rucker ,  David Charles Tully

IPC: C07D231/54 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/4162 ,  C07D471/04 ,  C07D471/06 ,  C07D491/052 ,  A61K31/416

Abstract: The present invention relates to compounds of Formula I, a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesoid X receptors (FXR).

公开(公告)号：US20220324863A1

公开(公告)日：2022-10-13

申请号：US17744432

申请日：2022-05-13

Applicant: NOVARTIS AG

Inventor： Jan Jiricek ,  Isabelle K. Lerario ,  Fang Liang ,  Xiaodong Liu ,  Valentina Molteni ,  Advait Suresh Nagle ,  Shuyi Pearly NG ,  Maxim Ratnikov ,  Jeffrey M. Smith ,  Yongping Xie

IPC: C07D471/04 ,  A61P33/02 ,  C07D519/00

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.