公开(公告)号：US20220356236A1

公开(公告)日：2022-11-10

申请号：US17809941

申请日：2022-06-30

Applicant: NOVARTIS AG

Inventor： Chad Eric BIGELOW ,  Ana Maria CARRION ,  James Edgar CHASTAIN ,  Kirk Lee CLARK ,  Bijan Alexandre ETEMAD-GILBERTSON ,  Joy Gispati GHOSH ,  Shawn Michael HANKS ,  Nicole HAUBST ,  Ganesh Rajan IYER ,  Nina MOKER ,  Andrew Anh NGUYEN ,  Stephen Hendrick POOR ,  Yubin QIU ,  Nalini Velamur RANGASWAMY ,  Michael STEFANIDAKIS ,  Engin TOKSOZ ,  Michael Zbigniew TWAROG

IPC: C07K16/22 ,  A61P27/02 ,  C07K16/46

Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.

公开(公告)号：US20220348646A1

公开(公告)日：2022-11-03

申请号：US17809943

申请日：2022-06-30

Applicant: NOVARTIS AG

Inventor： Chad Eric BIGELOW ,  Ana Maria CARRION ,  James Edgar CHASTAIN ,  Kirk Lee CLARK ,  Bijan Alexandre ETEMAD-GILBERTSON ,  Joy Gispati GHOSH ,  Shawn Michael HANKS ,  Nicole HAUBST ,  Ganesh Rajan IYER ,  Nina MOKER ,  Andrew Anh NGUYEN ,  Stephen Hendrick POOR ,  Yubin QIU ,  Nalini Velamur RANGASWAMY ,  Michael STEFANIDAKIS ,  Engin TOKSOZ ,  Michael Zbigniew TWAROG

IPC: C07K16/22 ,  A61P27/02 ,  C07K16/46

Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.

公开(公告)号：US20220025032A1

公开(公告)日：2022-01-27

申请号：US17375860

申请日：2021-07-14

Applicant: NOVARTIS AG

Inventor： Chad Eric BIGELOW ,  Ana Maria CARRION ,  James Edgar CHASTAIN ,  Kirk Lee CLARK ,  Bijan Alexandre ETEMAD-GILBERTSON ,  Joy Gispati GHOSH ,  Shawn Michael HANKS ,  Nicole HAUBST ,  Ganesh Rajan IYER ,  Nina MOKER ,  Andrew Anh NGUYEN ,  Stephen Hendrick POOR ,  Yubin QIU ,  Nalini Velamur RANGASWAMY ,  Michael STEFANIDAKIS ,  Engin TOKSOZ ,  Michael Zbigniew TWAROG

IPC: C07K16/22 ,  C07K16/46 ,  A61P27/02

Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.

公开(公告)号：US20210355206A1

公开(公告)日：2021-11-18

申请号：US17383319

申请日：2021-07-22

Applicant: NOVARTIS AG

Inventor： Joy Gispati GHOSH ,  Michael ROGUSKA ,  Mark Anthony RUTZ ,  Igor SPLAWSKI ,  Kathrin Ulrike TISSOT-DAGUETTE

IPC: C07K16/26 ,  C07K16/22 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention relates to compositions and methods for the inhibition of EPO. The invention provides antibodies and antigen binding fragments thereof that bind to EPO and are able to inhibit EPO-dependent cell proliferation and/or EPO-dependent cell signaling.