公开(公告)号：US20220025032A1

公开(公告)日：2022-01-27

申请号：US17375860

申请日：2021-07-14

申请人： NOVARTIS AG

发明人： Chad Eric BIGELOW ,  Ana Maria CARRION ,  James Edgar CHASTAIN ,  Kirk Lee CLARK ,  Bijan Alexandre ETEMAD-GILBERTSON ,  Joy Gispati GHOSH ,  Shawn Michael HANKS ,  Nicole HAUBST ,  Ganesh Rajan IYER ,  Nina MOKER ,  Andrew Anh NGUYEN ,  Stephen Hendrick POOR ,  Yubin QIU ,  Nalini Velamur RANGASWAMY ,  Michael STEFANIDAKIS ,  Engin TOKSOZ ,  Michael Zbigniew TWAROG

IPC分类号： C07K16/22 ,  C07K16/46 ,  A61P27/02

摘要： The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.

公开(公告)号：US20220356236A1

公开(公告)日：2022-11-10

申请号：US17809941

申请日：2022-06-30

申请人： NOVARTIS AG

发明人： Chad Eric BIGELOW ,  Ana Maria CARRION ,  James Edgar CHASTAIN ,  Kirk Lee CLARK ,  Bijan Alexandre ETEMAD-GILBERTSON ,  Joy Gispati GHOSH ,  Shawn Michael HANKS ,  Nicole HAUBST ,  Ganesh Rajan IYER ,  Nina MOKER ,  Andrew Anh NGUYEN ,  Stephen Hendrick POOR ,  Yubin QIU ,  Nalini Velamur RANGASWAMY ,  Michael STEFANIDAKIS ,  Engin TOKSOZ ,  Michael Zbigniew TWAROG

IPC分类号： C07K16/22 ,  A61P27/02 ,  C07K16/46

摘要： The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.

公开(公告)号：US20220348646A1

公开(公告)日：2022-11-03

申请号：US17809943

申请日：2022-06-30

申请人： NOVARTIS AG

发明人： Chad Eric BIGELOW ,  Ana Maria CARRION ,  James Edgar CHASTAIN ,  Kirk Lee CLARK ,  Bijan Alexandre ETEMAD-GILBERTSON ,  Joy Gispati GHOSH ,  Shawn Michael HANKS ,  Nicole HAUBST ,  Ganesh Rajan IYER ,  Nina MOKER ,  Andrew Anh NGUYEN ,  Stephen Hendrick POOR ,  Yubin QIU ,  Nalini Velamur RANGASWAMY ,  Michael STEFANIDAKIS ,  Engin TOKSOZ ,  Michael Zbigniew TWAROG

IPC分类号： C07K16/22 ,  A61P27/02 ,  C07K16/46

摘要： The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.